Anti-obesity medications mitigate weight regain in RYGB surgery patients


Researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery, according to a retrospective study published online in Obesity, the flagship journal of The Obesity Society.

“Our study provides evidence that medications can help, especially in situations where the is occurring at a rapid rate. Characterization of weight regain as a rate is novel and adds to the understanding of this important clinical problem,” said Nawfal Istfan, MD, Ph.D., associate professor of medicine at Boston University School of Medicine and attending physician at Boston Medical Center in Boston, Mass. Istfan is the corresponding author of the study.

Weight regain after gastric bypass is well recognized, normally occurring two years after the surgery and ultimately affecting 25 percent of patients. It is becoming increasingly urgent to mitigate its occurrence and preserve the metabolic and medical benefits of weight loss surgery. The application of pharmacologic agents to deal with this specific problem has been limited in the medical literature.

Researchers used the electronic medical records of nearly 1,200 multi-ethnic patients who underwent Roux-en-Y gastric bypass surgery between 2004 and 2015 at Boston Medical Center. The evaluation of weight regain was made by comparing each patient’s weight during subsequent, post-operative office visits to nadir weight (lowest weight after Roux-en-Y gastric bypass surgery), taking into consideration the interval during which weight regain occurred. Seven time intervals were used in the analysis ranging from before surgery to 6 years after surgery. Patients prescribed anti-obesity medications and who came for follow-up visits were classified as adherent users, whereas those who missed follow-up visits were considered non-adherent.

After using three independent statistical models, researchers demonstrated that anti-obesity medications decrease cumulative weight regain by about 10 percent relative to nadir weight and reduce the odds of rapid weight-regain occurrence after Roux-en-Y . Researchers also found that of the 760 patients who achieved nadir weight and are at risk for weight regain, 350 were documented users of anti-obesity medications.

These results take into account that patients typically lost weight when taking anti-obesity medications and regained weight during intervals when the medications were not prescribed. Additionally, patients started anti-obesity medications at different stages and used them at variable and intermittent periods.

The authors noted that the full potential of phentermine and topiramate and newer anti-obesity medications to counter weight recidivism and prevent the reoccurrence of obesity-related comorbidities need to be explored in further prospective clinical trials. Guidelines also need to be established for initiating and monitoring the potential long-term use of anti-obesity medications after bariatric surgery.

“One of the ways to address this particular set of limitations in future study with a prospective clinical trial would be to set specific protocols regarding use of anti-obesity medications by providers. Specifically, providing education for providers on individual anti-obesity medications for them to understand mechanisms of action, then separately creating a clinical workflow to incorporate use of anti-obesity medications, in particular settings of recidivism,” said Crystal Johnson-Mann, MD, assistant professor, Department of Surgery, Division of Gastrointestinal Surgery, at the University of Florida College of Medicine in Gainesville. “For optimal results in a prospective trial, individual prescribing tendencies (or lack of prescribing) needs to be eliminated and be uniform across all of the providers involved in the care of these patients post-operatively.”

The study, titled “The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery” will be published in the June 2020 print issue.


Study finds weight loss lasts long after surgery


More information:
“The Mitigating Effect of Phentermine and Topiramate on Weight Regain after Roux-en-Y Gastric Bypass Surgery” onlinelibrary.wiley.com/doi/10.1002/oby.22786

Citation:
Anti-obesity medications mitigate weight regain in RYGB surgery patients (2020, May 22)
retrieved 22 May 2020
from https://medicalxpress.com/news/2020-05-anti-obesity-medications-mitigate-weight-regain.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



loading...

Related posts:

SARS-CoV-2 geht an die Nieren – welche therapeutischen Konsequenzen sind zu ziehen?
Retinal texture could provide early biomarker of Alzheimer's disease
Entwicklung maschineller Lernverfahren: Großer maschinenlesbarer EKG-Datensatz veröffentlicht
Sehen ist ein Entscheidungsprozess - Biermann Medizin
Antivirales Medikament gegen COVID-19 erstmalig am Dresdner Uniklinikum erfolgreich eingesetzt
the hunt for the antibody to treat COVID-19
Up to 60% of students in some schools vaped in past month
Gene inactivation of PTEN drives cancer predisposition
Mayo Clinic Minute: Health benefits of gardening
Professor Christoph Keplinger bringt neue Robotergeneration nach Deutschland
MRI pregnancy study gives new insights into the all-important placenta
High-tech devices help NFL teams keep players safe, in shape
First-of-its-kind-study reveals that eating prior to cardiac catheterization is non-inferior to fast
Turning to wine during lockdown? Here's how to protect your teeth
Americans and Europeans soak up the sun amid new rules
MB-Online-Umfrage: Ärzte für behutsame Rückkehr zum Regelbetrieb
Canada and the U.S. working on extending border closure
E-Zigaretten: Experten sind uneins über den Nutzen der E-Zigarette bei der Entwöhnung
WIdO-Studien belegen Zusammenhang zwischen Fallzahl und Qualität bei Hüft- und Knieprothesenwechseln
Madagascar's 'green gold' against COVID-19 seeks nod beyond Africa
Clinical trial shows ability of stem cell-based topical solution to regrow hair
Lymph node metastases form through a wider evolutionary bottleneck than distant metastases
Madagascar reports first coronavirus death
CT findings of coronavirus disease (COVID-19) in children 'often negative'
COVID-19: Studie zur Therapie der schweren Entzündungsreaktion
New research shows that increasing number of lost pregnancies is linked to higher risk of developing...
Antihormonelle Krebstherapien auf dem Weg zur Gleichberechtigung
SARS-CoV-2: Möglicher protektiver Effekt durch Androgenentzug
Turkey confirms 32 deaths, 1,141 new COVID-19 cases
Some recommended cardiovascular medications prescribed less frequently to women
Europe reopens widely; China gives $2 billion to virus fight
DKOU 2020 abgesagt - Biermann Medizin
WHO: Corona-Ansteckung durch Berührung von Oberflächen nicht bewiesen
Study reveals 'extensive' financial links between leaders of US medical societies and industry
Surgery and radiation do not extend survival in newly diagnosed metastatic breast cancer
'Knowing how' is in your brain
Treating skin irritations from wearing face masks
SARS-CoV-2 verstehen: Forschungsprojekte ergründen Eigenschaften und Ausbreitung
The prevention of childhood obesity would require stricter advertising regulations
These coronavirus 'carriers' take test samples around London
Krankheitsauslöser für Pankreatitis identifiziert - Biermann Medizin
Air filters shown to improve breathing in children with asthma
Vaccine hopes and economic woes as virus spreads
Regular aspirin use tied to lower risk for digestive tract cancers
Large-scale vaccine testing expected by July
Coronavirus reminds you of death—and amplifies your core values, both bad and good
Göttingen: DFG verlängert Förderung des Sonderforschungsbereiches „Herzschwäche“
Preventing 'cytokine storm' may ease severe COVID-19 symptoms
Virus could cut up to 9.7 percent off global economy: ADB
Dr. Ecker erhält Preis für Notfallmedizin
Ein Wachstumsfaktor für Blutgefäße als Schutzfaktor für metastasierende Tumorzellen
Den Immunzellen in Hirntumoren auf der Spur
Virus cases drop to zero in China but surge in Latin America
Virus count revised, new clusters emerge as France reopens
Erfolgreicher Sonderforschungsbereich zu Hepatitis-Viren und Immunabwehr
Demenz-Gen erhöht das Risiko für schweres COVID-19
Have a reusable face mask? Here's how to wash it the right way
Walking or cycling to work associated with reduced risk of early death and illness
Erfolgreiche Zertifizierung als Audiologisches Zentrum
Avoid E. coli with proper burger cooking
Lagerungsschwindel – Einfache Frage zur Diagnose?
Multi-drug regimen for heart failure could meaningfully extend patients' lives
AbbVie schließt Übernahme von Allergan ab
Ultraviolet light has bright future in fight against COVID-19
India backs hydroxychloroquine for virus prevention
Antikörper erkennt Alzheimer-Pathogene - Biermann Medizin
COVID-19 Lungenentzündung: Sicher, rasch und standardisiert mittels Ultraschall-Protokoll erfassen
Landmark recommendations on development of artificial intelligence and the future of global health
Turkey registers 41 new deaths, lowest since end of March
Researchers identify mechanisms that make skin a protective barrier
SARS-CoV-2-PCR-Tests erreichen Rekordniveau – Zahl der Antikörpertests steigt
Heart attacks, heart failure, stroke: COVID-19's dangerous cardiovascular complications
Bindehautinfektion durch SARS-CoV-2 unwahrscheinlich - Biermann Medizin
Mortalitätsrate unter jungen Epileptikern weiter hoch
Kritik am Patientendaten-Schutzgesetz - Biermann Medizin
Schmerzen bei Rheuma: Immer mehr Patienten nehmen Opioide ein
Hospital response risks worsening health inequalities
Blood flow recovers faster than brain in micro strokes
Neue Erkenntnisse zu Hepatitis C bei Säuglingen könnte zu besseren Therapien führen
Biomarkers may help us understand recovery time after concussion
Leberkrebs: Forderung nach mehr Aufmerksamkeit in Bezug auf Hepatitis D
COVID-19 patients who undergo surgery are at increased risk of postoperative death
Coronavirus-Infektionen können zu Delir und PTSD führen
Immunantwort nach Corona-Infektion im Blick
COVID-19 patients may have lower stroke rates than previously suggested
Coronavirus cases top five million worldwide
Sondererhebung in der Corona-Krise: Medizinklimaindex fällt auf -25,1
Japan set to lift coronavirus emergency as cases slow
Nearly quarter of a billion people in Africa will catch coronavirus and up to 190,000 could die
Deutsche Krebshilfe und die Arbeitsgemeinschaft Dermatologische Prävention raten zu neuer Normalität...
Ärzte-Statistik: 402.000 Ärzte in Deutschland
What can a COVID-19 antibody test tell me?
Faktencheck: Augenherpes wegen Mundschutz? Zusammenhang nicht belegt
Norditalien: COVID-19-Sterbezahlen bilden Auswirkungen der Pandemie nur unvollständig ab
France virus toll nears 28,500 as daily deaths slow
Early indicators of vaccine efficacy
Selbsttonometrie und telemedizinischer Datentransfer: Kick-off-Video zum SALUS-Projekt jetzt online
Minimum legal age for cannabis use should be 19, study suggests
Mediziner fordern vollständige Öffnung von Schulen und Kitas
Epilepsy-related deaths common in young adults and are not reducing, new research shows

Leave a Reply

Your email address will not be published. Required fields are marked *

Next Post

47 kosovarë kthehen nga Sllovenia

Fri May 22 , 2020
47 kosovarë janë kthyer nga Sllovenia në Kosovë. me anë të një komunikate për media Ambasada e Sllovenisë, njofton që  në koordinim me institucionet e Kosovës dhe Sllovenisë është mundësuar kthimi në Kosovë i 47 bashkëatdhetarëve që ishin në Slloveni. “Transporti është organizuar nga Ambasada e Kosovës në Lubjanë dhe […]