Biomarkers may help us understand recovery time after concussion


concussion
Credit: CC0 Public Domain

A blood test may help researchers understand which people may take years to recover from concussion, according to a study published in the May 27, 2020 online issue of Neurology, the medical journal of the American Academy of Neurology. The study looked at a biomarker called neurofilament light chain, a nerve protein that can be detected in the blood when nerve cells are injured or die.

Researchers found that, years later, people with a history of three or more concussions were more likely to have high levels of the biomarker than people who had not had a . High levels of the biomarker were also associated with more such as post-traumatic stress disorder and depression years after the concussions occurred.

“While most people with mild concussions recover completely, some never get their lives back fully because of chronic disability,” said study author Kimbra L. Kenney, M.D., of the National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, Md., and a Fellow of the American Academy of Neurology. “These people may benefit greatly from a test that could predict those disabilities years ahead of time. Our study found there’s great potential for this protein to predict the problems people with concussions may experience years after their injuries.”

The study involved 195 with an average age of 38; 85 percent were male. Participants were divided into three groups: 45 people with no history of concussions, 94 people with one or two concussions, and 56 people with three or more concussions. It had been at least seven years since the last concussion for the participants. They were also tested to confirm whether they had symptoms of post-, depression or post-concussive syndrome, which refers to lingering symptoms like mood changes, memory problems and headaches after a concussion.

Blood samples were taken to determine levels of the protein in participants. Then they measured levels of protein in the overall as well as in the exosomes found in the blood. Exosomes are like tiny bubbles that carry and other information between cells. The average blood levels of neurofilament light were 33% higher in those with three or more concussions than those who had never had a concussion. Exosomal levels were similarly 34% higher in those with multiple concussions. Two other proteins associated with inflammation were also increased in those with multiple concussions.

“The main finding in the study is that people with multiple concussions have more of these proteins in their blood, even years after the last injury,” said Kenney. “Additionally, these proteins may help predict who will experience more severe symptoms such as PTSD and depression. That’s exciting because we may be able to intervene earlier to help lessen the overall effects of concussions over time.”

Kenney said a limitation of the study was the relatively small number of people involved and the need to verify these results in a much larger, separate group of people.


After concussion, biomarkers in the blood may help predict recovery time


Citation:
Biomarkers may help us understand recovery time after concussion (2020, May 27)
retrieved 28 May 2020
from https://medicalxpress.com/news/2020-05-biomarkers-recovery-concussion.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



(Visited 2 times, 1 visits today)

Related posts:

With social distancing, schools should be safe to reopen this fall, experts say
Why We Still Don’t Know Enough About Covid-19 and Pregnancy
U.S. sees another record-breaking day of new coronavirus cases
Widow of French bus driver beaten to death over masks says family is 'destroyed'
Five killed after gunmen storm a South African church, 40 people arrested
Coronavirus Live Updates: As U.S. Cases Rise, States Weigh New Restrictions
Physicians give first comprehensive review of COVID-19's effects outside the lung
LGBT rights at heart of Poland presidential-election fight
Study of Coronavirus in Pregnant Women Finds Striking Racial Differences
Coronavirus deaths take a long-expected turn for the worse
How Covid-19 can damage the brain
Malian anti-govt protests continue despite president's call for dialogue
How to Reopen Schools: What Science and Other Countries Teach Us
Virus cases up sharply in Africa, India as inequality stings
Study highlights multiple health risks among a people living longer with HIV
Jack Charlton, icon of English and Irish football alike, dies at 85
Couldn't socially distance? Blame your working memory
Is what I see, what I imagine? Study finds neural overlap between vision and imagination
Fury in France as protesters slam Macron’s choice of interior minister accused of rape
Abnormally high blood sugar linked with higher risk of death in COVID-19 patients not previously dia...
WHO urges aggressive virus measures as flare-ups spark new closures
US records 63,643 new virus cases in 24 hours
Bosnian Muslims mark 25th anniversary of Srebrenica massacre
Brazil surpasses 70,000 coronavirus deaths
Nano-radiomics unveils treatment effect on tumor microenvironment
Malian president urges calm in overnight address after protesters take state TV off air
Hong Kong opposition pushes ahead with primaries under shadow of security law
US bets on untested company to deliver COVID-19 vaccine
Trump commutes prison sentence of longtime friend Roger Stone
Serbia reports record daily virus death toll
Nearly half of US adults projected to be obese by 2030
Building surge ICU capacity during COVID-19
New research suggests failure to retrieve relevant details from memory may underlie face blindness
Study pinpoints brain cells that trigger sugar cravings and consumption
Cancer health disparities published in new volume
France virus death toll exceeds 30,000
Uzbekistan reimposes virus lockdown after new cases
The people tirelessly restoring Notre-Dame to its former glory
A Confederate flag spotted in the window of police barracks in Paris
Pandemic inspires framework for enhanced care in nursing homes
Mali protesters demand president's resignation over jihadist conflict, economy
They got a big ER bill because hospitals couldn't test for virus
Milde und schwere COVID-19-Erkrankung: Unterschiede der Immunreaktion gegen SARS-CoV-2
Instagram to block all content promoting LGBT ‘conversion therapy’
Serbia, Kosovo resume ‘very difficult’ talks on normalising ties
Coronavirus can still be brought under control: WHO
Kein erhöhtes Demenzrisiko durch Tiefe Hirnstimulation
Balloons bring internet to Kenya's rural Rift Valley
How do COVID-19 antibody tests differ from diagnostic tests?
Virtueller DIVI-Kongress als Novum für 6.000 Teilnehmer
Decades on, 'hidden children' forced into orphanages of colonial France remain traumatised
Macron revamps cabinet, France rules out new lockdown and Louvre reopens
Fat cell hormone boosts potential of stem cell therapy
Neue Studie von UKE-Forschenden: SARS-CoV-2 befällt auch das Herz
UK travellers hope to salvage holidays as government eases quarantine rules
WHO special envoy on Covid-19 'extremely worried' about rise in cases worldwide
Sutter Health’s Request to Delay $575 Million Settlement Is Denied
Florida's curve no longer flat amid new surge of virus cases
DGK für Engagement in der Corona-Krise ausgezeichnet
Turkish court paves way to reconverting Hagia Sophia museum into a mosque
Netherlands takes Russia to European court over 2014 downing of Flight MH17
Coronavirus Live Updates: U.S. Nears 60,000 New Daily Cases
Largest study of prostate cancer genomics in Black Americans IDs targets for therapies
Medienpreis Urologie für fundierte Berichterstattung im Zeitalter von Dr. Google
Teletherapy, Popular in the Pandemic, May Outlast It
Ozone disinfection could safely allow reuse of personal protective equipment
COVID-19-Pandemie: Mehr Fälle des Brocken-Heart-Syndroms
The many lives of Hagia Sophia, Istanbul’s ‘wonder of wonders’
Meet the Heroes Fighting on the Front Lines Against Covid-19
How COVID-19 lockdown has impacted people with arthritis
Intensivmedizin an der Universitätsmedizin Göttingen wird erweitert
PSG to face Italy's Atalanta in Champions League quarter-finals
Study reveals circuit mechanism underlying nociceptive information processing
Kurznotizen am Erbgut - Biermann Medizin
Hong Kong to shut all schools after virus cases spike
Umfrage: Videosprechstunden bekommen in Corona-Krise Schwung
Lebanon’s neo-liberal wheels sped to a dream future, but the past applies the brakes
China vows to hit US with 'reciprocal measures' after Xinjiang sanctions
Why India cases are rising to multiple peaks
Ein Datenschatz für die Ganganalyse
Researchers identify key role of immune cells in brain development
Merkel press office staffer 'worked for years for Egyptian intelligence'
France investigates report of bodies 'left to rot' at Paris research centre
New study supports remdesivir as COVID-19 treatment
Neues Proteomik-Verfahren: Detaillierter Einblick in die gestresste Zelle
US sees latest record surge in virus cases amid wrangling over lockdown measures
Air Pollution Takes a Global Toll on Heart Health
Indoor airborne spread of coronavirus possible
Australia locks down second city as global cases top 12 million
Serbia drops plans for reimposed lockdown after days of violent protests
WHO launches global pandemic response probe
French César awards announce changes in response to Polanski #MeToo brouhaha
Airborne coronavirus transmission raises new questions and worries
Forecasts predict worse EU recession since WWII
reducing your risk of kidney stones
Scientists discover protective Alzheimer's gene and develop rapid drug-testing platform
UK declines participating in EU Covid-19 vaccine scheme over concerns of delays
Technology Bridges the Gap to Better Sight
CT of COVID-19 versus CT of influenza virus pneumonia
Bolivia's President Anez tests positive for Covid-19

Leave a Reply

Your email address will not be published. Required fields are marked *