Dry powder inhalation could be a potent tool in COVID-19 antiviral treatment


Dry powder inhalation could be a potent tool in COVID-19 antiviral treatment
A microscopic image of remdesivir powder formulations after the thin-film freezing process. All formulations exhibited a brittle matrix structure of highly porous particles. Credit: University of Texas at Austin

The only antiviral drug currently used to treat SARS-CoV-2, the coronavirus that causes COVID-19, is remdesivir, but administering it is invasive and challenging. Scientists at The University of Texas at Austin are hoping to change that by using their novel thin-film-freezing technology to deliver remdesivir through dry powder inhalation, potentially making treatment more potent, easier to administer and more broadly available.

A team of researchers in UT Austin’s Division of Molecular Pharmaceutics and Drug Delivery, led by Robert O. (Bill) Williams III, has investigated varying methods of to repurpose existing drugs into more efficacious forms. Earlier this year, the team focused on niclosamide, confirmed to exhibit antiviral efficacy in COVID-19 infected cells. Since then, remdesivir has emerged as the only available antiviral treatment for coronavirus.

Remdesivir is authorized for emergency use in adult and hospitalized with severe disease. Originally developed to treat the Ebola virus disease, remdesivir has shown promising results treating COVID-19 in the human airway epithelial cells. However, limited effective delivery methods have hindered efforts to provide widespread treatment to a broad range of patients exhibiting life-threatening symptoms.

“Unfortunately, remdesivir is not suitable for oral delivery since the is mostly metabolized by the body,” Williams said. “Intramuscular injection also faces challenges, since release rates from the muscles can vary widely.”

To provide remdesivir for other patients beyond the most severely ill, more convenient and accessible dosage forms for different routes of administration must be quickly developed and tested so patients have more options to get treated. One way to overcome the poor absorption rates of remdesivir is to deliver it directly to the infection site. The research team, which includes Sawittree Sahakijpijarn, Chaeho Moon and John J. Koleng, has developed inhaled forms of remdesivir for protecting and treating the respiratory mode of infection, including an amorphous brittle matrix powder made by thin-film freezing. Not only would this delivery method allow for wider distribution of an essential antiviral in the fight against COVID-19, it could also make remdesivir more effective.

“If patients can avoid a hospital visit to begin treatment, it can lessen the current strains on our health system, lower cost and provide fewer points of contact with those who are still contagious,” Williams said. “More widely available early stage intervention methods could significantly lesson symptoms before they become potentially life-threatening, providing more hospital beds and ventilators to those who need them the most.”

TFF Pharmaceuticals Inc. has acquired the patents regarding thin-film freezing and inhalation. The UT researchers’ findings were recently published as a preprint in bioRxiv. Upon final study results, the team will submit its full findings for peer review and publication.


Canada OKs remdesivir for use against coronavirus


More information:
Chaeho Moon et al. Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing, (2020). DOI: 10.1101/2020.07.26.222109

Citation:
Dry powder inhalation could be a potent tool in COVID-19 antiviral treatment (2020, July 29)
retrieved 29 July 2020
from https://medicalxpress.com/news/2020-07-powder-inhalation-potent-tool-covid-.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Related posts:

Scientists Uncover Biological Signatures of the Worst Covid-19 Cases
Research leads to simplified dosage of HIV medicine for children
Colombian ex-president Uribe detained for alleged witness tampering, he says
F.D.A. Adds More Hand Sanitizers to List of Products to Avoid
Beirut blasts damage UN peacekeeping ship, president calls state of emergency
Many COVID-19 patients given useless antibiotics, study finds
Offers of assistance pour in for Lebanon after deadly Beirut explosions
Forget Spas and Bars. Hotels Tout Housekeeping to Lure Back Travelers.
Defending champ Nadal to skip US Open over coronavirus concerns
Mysterious paralyzing illness in kids is set to return, CDC warns
Novavax's New Covid-19 Vaccine Studies Praised By Scientists
HIIT programs show benefits for those with Down syndrome
Nach den Sommerferien: Zurück in Schule und Kindergarten!
Live Coronavirus Tracker - The New York Times
Once popular former king goes into exile amid scandal
Parasite resistance to antimalarial artemisinin derivatives now affecting Africa
Geriatrische Patienten nach Cochlea-Implantation - Biermann Medizin
France's Charles-de-Gaulle airport enforces Covid-19 testing on arrival
Identification of a new mechanism in the immune system provides knowledge about diseases
Wie sich psychologischer Stress auf Immunzellen auswirkt
Are we 'Waiting for Godot?' A metaphor for COVID-19
Unterschiede in den klinischen Merkmalen nicht adipöser Patienten mit NAFLD
Massive explosion rocks Lebanese capital Beirut
Dear Dr... how our email style reveals much about our personalities
Für Kinder steigt in den Ferien das Unfallrisiko
Researcher seeks safer, more effective leukemia treatment
Schlüsselgen für die Bildung von Herzklappen entdeckt
Macron announces coronavirus bonus for France's homecare workers
Red Onions Linked to Salmonella Outbreak, Officials Say
How we found coronavirus in a cat
MAFLD: Körperliche Fitness ist bedeutsamer als reiner Gewichtsverlust
Coronavirus Live Updates: Fight Over Aid Package Drags On
Insufficient evidence of reduced COVID-19 incidence at high altitudes
Macht eine „Immunthrombose“ das Coronavirus so gefährlich?
Niger marks 60 years of independence from France
Cameroonian migrant killed in Morocco after police find forest encampment
Norway cruise ship passengers with coronavirus reach 43
Studie: Candida-Cluster verursachen in unterschiedlichen Krankenhäusern schwere Infektionen
France facing ‘highly likely’ second wave of Covid-19 in autumn or winter
The reluctant candidate taking on Europe’s ‘last dictator’
France risks losing control of coronavirus: science council
Erstes Medikament gegen Hepatitis D von der Europäischen Kommission zugelassen
Trump’s ‘inexperienced and unqualified’ ambassadors leave US allies aghast
Blood test could diagnose baby brain damage just hours after birth
„Sicherer als ein Flug nach Mallorca“: Vorbereitungen für RESTART-19-Experiment laufen
African American BMi associated with severe COVID-19 and ICU admission
Glücklose „Glückspille“: Fluoxetin bessert funktionelle Fähigkeiten nach Schlaganfall nicht
Latin American virus cases top 5 million
Stranded men rescued from Pacific island after writing SOS in sand
Immunization programs yield high 'return on investment,' saving hundreds of billions of dollars
Millions back under lockdown in Philippines amid surge in virus cases
This 'actions-speak-louder-than-words' student puts public policy studies to work
Norway restricts cruise ship arrivals after Covid-19 outbreak on vessel
Penis microbiota predicts if a man's female partner will develop bacterial vaginosis
Fortschritte beim Bluttest auf Alzheimer
Tackling the bioethics challenges raised by COVID-19
Trial of Algerian journalist and press freedom icon Khaled Drareni starts in Algiers
New York attorney probing Trump and his business over 'criminal conduct'
How COVID-19 changed the way patients responded to a heart attack
Isaias strengthens back to a hurricane forecast to hit Carolinas and East Coast
Dementia on the Retreat in the U.S. and Europe
WHO advance team ends visit to China to probe COVID origin
Doubt cast on wisdom of targeting 'bad' cholesterol to curb heart disease risk
Asthma drug (beta2-agonists) can boost sprint and strength performance in athletes
Israeli jets strike targets in Syria after attempted attack in Golan Heights
Trump says he will only allow TikTok sale if US government gets a cut
2.5% of Italians had COVID-19, far more in the north
Half of low-income communities have no ICU beds
Greater financial integration generally not associated with better healthcare quality
Neue effektive Behandlungsform bei akuter Leukämie
An averted glance gives a glimpse of the mind behind the eyes
Gewissheit in nur 15 Minuten mit graphen-oxidbasiertem Schnelltest zur Infektionserkennung
Child sleep problems associated with impaired academic and psychosocial functioning
COVID-19 oder nicht? Röntgen-Software kann bei der Diagnose unterstützen
Former king Juan Carlos to leave Spain amid probe over financial scandal
Covid-19 Testing Is in Short Supply. Should You Still Get a Test?
Racial discrimination linked to suicide
Neue dermato-onkologische Strategien werden beim ersten digitalen Deutschen Hautkrebskongress vorges...
France halts ratifying extradition treaty with Hong Kong in wake of security law
Scientists Worry About Political Influence Over Coronavirus Vaccine Project
Four-stranded DNA structures found to play role in breast cancer
Schulbeginn: Deutsche Dermatologische Gesellschaft (DDG) empfiehlt Hände desinfizieren statt zu viel...
How the city is adapting to keep visitors safe
Is Telemedicine Here to Stay?
The effects of COVID-19 on emergency visits, hospitalizations
FMT: Präzisere Therapie durch genaueren Blick ins Mikrobiom
Drugmaker Sanofi charged with manslaughter over birth defects
Share Your Medical Bills for Coronavirus
Outbreak hits Norway cruise ship, could spread along coast
Nicht invasiver Bluttest erkennt Krebs vier Jahre früher als herkömmliche Diagnoseverfahren
Videos of Nigerian wedding massacre, mass burials go viral amid call for end to ethnic violence
Rules on outdoor mask-wearing go into effect for parts of France hardest hit by Covid-19
Providers: How Has Covid-19 Changed Your Practice?
Poverty is the most significant obstacle to happiness and well-being for children in England, report...
Boehringer Ingelheim steigert Umsatz - Biermann Medizin
Hundreds of militants remain at large after Islamic State group attack on prison
Spared from fire, Notre-Dame's organ set for lengthy restoration
‘The Biggest Monster’ Is Spreading. And It’s Not the Coronavirus.
A snapshot of how everyday life changed during the first coronavirus lockdown
COVID-19: Steigende Fallzahlen, aber keine akute Überlastung des Gesundheitswesens

Leave a Reply

Your email address will not be published. Required fields are marked *

Next Post

Gjilan, banesa përfshihet nga zjarri

Wed Jul 29 , 2020
Dje në rrugën e ‘Gjinollëve’ në Gjilan është raportuar për një banesë të përfshirë nga zjarri. Sipas raportit policia ka dalë në vendin e ndodhisë, kurse zjarrfikësit kanë shuar zjarrin. Ne raport tutje thuhet se për shkaqe të sigurisë është bërë evakuimi i disa banorëve deri sa është shuar zjarri […]