Multi-drug regimen for heart failure could meaningfully extend patients’ lives


heart failure
Credit: CC0 Public Domain

Patients with heart failure have substantially shorter life expectancies than people without this condition. Approximately 6.5 million people in the U.S. and over 64 million people worldwide have heart failure, and about half of them have heart failure with reduced ejection fraction (HFrEF). In the last three decades, there have been many advancements in the treatment of HFrEF with several new drugs showing promising results in randomized, controlled clinical trials. However, uptake of new therapies has been slow. A team led by investigators from Brigham and Women’s Hospital has conducted an analysis to estimate the potential benefits of using a comprehensive regimen that incorporates newer therapies into clinical practice compared to using a more conventional regimen. The team found that comprehensive therapy could extend lifespan up to six years and eight years free from cardiovascular death or first hospital admission for HFrEF. Results are published in The Lancet.

“There’s been some resistance to adopting comprehensive therapy for ,” said corresponding author Scott Solomon, MD, of the Brigham’s Cardiovascular Division. “What we did here was to say, ‘What might the benefit be over a patient’s lifetime?’ And the benefit we’re seeing is pretty dramatic.”

“Across a broad range of ages, these therapies, when implemented in combination, may meaningfully improve life expectancy and help patients remain out of the hospital,” said lead author Muthiah Vaduganathan, MD, MPH, also of the Brigham’s Cardiovascular Division.

To conduct their analysis, Solomon, Vaduganathan and colleagues leveraged data from three previously conducted randomized, . Each trial evaluated a therapy for heart failure patients: mineralocorticoid receptor antagonists (MRA), angiotensin receptor-neprilysin inhibitors (ARNI), and sodium/glucose cotransporter (SGLT2) inhibitors. Drawing on the data from these trials, the team conducted an actuarial analysis to estimate the lifetime benefit of taking all three drugs in addition to a conventional regimen.

Their analysis found that over the course of a lifetime of use, assuming consistent treatment benefits, the comprehensive regimen could add up to eight years of survival free from cardiovascular events and hospitalization due to heart failure. While younger patients with HFrEF would stand to benefit the most, the researchers reported gains in for all age groups analyzed.

Offering readily understandable metrics for clinicians and patients to be able to refer to when discussing treatment options was important to the authors, especially amid the COVID-19 pandemic.

“Patients with failure are especially vulnerable during COVID-19 and ensuring effective preventive care for this high-risk segment of the population is a top priority in the next phase of the pandemic planning,” said Vaduganathan.

The authors note that their analysis has certain limitations, including assumptions about the , adherence, and that benefits would continue to accrue over time. In addition, the analysis does not examine the costs of drugs or the potential side effects—such as kidney toxicity—of taking these drugs in combination.


Diabetes drug effective against heart failure in wide spectrum of patients


More information:
Vaduganathan M et al. “Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials” The Lancet DOI: 10.1016/S0140-6736(20)30748-0

Citation:
Multi-drug regimen for heart failure could meaningfully extend patients’ lives (2020, May 21)
retrieved 21 May 2020
from https://medicalxpress.com/news/2020-05-multi-drug-regimen-heart-failure-meaningfully.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



loading...

Related posts:

Dr. Ecker erhält Preis für Notfallmedizin
Heart failure patients with limited health literacy may have higher risk of death
Insomnia may forecast depression, thinking problems in older people
Study quantifies China's chronic health burden for the first time
BCG: Warnung vor latenten Infektionen
Virologe Streeck wehrt sich gegen Vorwürfe: „Doof gelaufen“
New research into stem cell mutations could improve regenerative medicine
COVID-19 and people with disabilities
WHO suspends hydroxychloroquine trial as COVID-19 treatment
Researchers link gene mutation to autism behaviors
COVID-19 und der neue Alltag mit Maske: Welche sind wofür geeignet?
Voluntary collective isolation is best response to COVID-19 for indigenous populations
Schulterschluss der Herzmedizin – Wir dulden keinen Rassismus
Schwangerschaft: "Natürlich" bedeutet nicht automatisch gesund
Apremilast bei pädiatrischer Psoriasis
Misleading information in 1 in 4 most viewed YouTube COVID-19 videos in English
Africa's tech scene tackles virus
Leibniz-WissenschaftsCampus EvoLUNG erhält erneut Förderung
COVID-19 death counts 'substantial underestimation' of actual deaths for some Italian regions
Krankheitserreger nutzen Stickstoffmonoxid bei der Schleimhaut-Besiedlung
Are we wired for romance? fMRI imaging and genetic analysis say yes
Vienna Philharmonic says no increased virus risk for orchestras
Russia's virus spread stabilising: top health official
Mediziner fordern vollständige Öffnung von Schulen und Kitas
Mayor says Mexico City will begin gradual reopening June 1
Chicago Latinos see higher rates of COVID-19 infections
Lagerungsschwindel – Einfache Frage zur Diagnose?
Krankheitsauslöser für Pankreatitis identifiziert - Biermann Medizin
beacons of Latin American virus success
Mortality rates hint at even higher coronavirus death toll
Roboter hilft Pflegenden - Biermann Medizin
SARS-CoV-2 geht an die Nieren – welche therapeutischen Konsequenzen sind zu ziehen?
SARS-CoV-2-PCR-Tests erreichen Rekordniveau – Zahl der Antikörpertests steigt
COVID-19 könnte bei Kindern schwere Entzündungserkrankung verursachen
To become happy, people need enough time... But how much is enough?
Small risk of muscle and bone problems in babies of mothers who took common thrush treatment
High-tech devices help NFL teams keep players safe, in shape
Research shows electroceutical fabric eradicates coronaviruses on contact
COVID-19: Ulmer Forscher untersuchen in neuer Therapiestudie Wirkung von Ruxolitinib
Selbsttonometrie und telemedizinischer Datentransfer: Kick-off-Video zum SALUS-Projekt jetzt online
Neue Angiographie-Einheit erweitert Behandlungsmöglichkeiten deutlich
New research finds 'Dr. Google' is almost always wrong
Lidar used to track mosquito activity in Africa to help combat malaria
Newborn may have contracted coronavirus in the womb
Hobbies may help defeating depression
Schmerzmedizin im Krankenhaus unter SARS-CoV-2-Bedingungen
How mindfulness can help amid the COVID-19 pandemic
Why pancreatic ductal adenocarcinoma is so lethal
Children may not always grow out of being picky eaters: study
First prospective study of critically ill COVID-19 patients in NYC
Neue App für Pollen-Allergiker - Biermann Medizin
COVID-19 patients may have lower stroke rates than previously suggested
Beim Fahrradfahren zum Infektionsschutz zusätzlich an den Kopfschutz denken
Treating skin irritations from wearing face masks
Is your job killing you? Stress, lack of autonomy, ability can lead to depression, death
MB-Online-Umfrage: Ärzte für behutsame Rückkehr zum Regelbetrieb
Overcoming challenges of individuals with autism during the COVID-19 pandemic
Hilfe für Beatmungspatienten: Mit Salbe soll Sauerstoffaufnahme über die Haut erhöht werden
Turning to wine during lockdown? Here's how to protect your teeth
Angst vor COVID-19 verzögert Diagnose und Therapie bei Krebspatienten
Germany kicks off as Europe eases curbs but virus marches on
Neue Erkenntnisse zur Wirkweise von Ketamin
First-of-its-kind-study reveals that eating prior to cardiac catheterization is non-inferior to fast
Madagascar's 'green gold' against COVID-19 seeks nod beyond Africa
Problems with alcohol? 29 gene variants may explain why
Spain govt seeks 2-week extension of lockdown
'Time is vision' after a stroke
Antibody designed to recognize pathogens of Alzheimer's disease
If prescribed opioids for pain, ask lots of questions: FDA
DGVS mahnt Rückkehr zur regulären Früherkennung an
Live poultry linked to Salmonella cases in 28 states
Daily Internet use is linked to social isolation
Abnormalities detected on brain MRI of COVID-19 patients in ICU
Im März die meisten Laufverletzungen
Local health agencies struggle to ramp up virus tracking
As US, Europe reopen more, big nations see rising virus toll
SARS-CoV-2: Möglicher protektiver Effekt durch Androgenentzug
Cavity-causing bacteria assemble an army of protective microbes on human teeth
Coronavirus may never go away: WHO
Brazil surges to second in coronavirus cases worldwide
HCC: Neue Kombinationstherapie könnte Überleben von Patienten verlängern
Coronavirus cases top five million worldwide
EU calls for independent probe of WHO's pandemic response
Madagascar reports first coronavirus death
App will reduce high risk of falls during and after lockdown
Loosened restrictions, holiday weekend to test California
For young health care worker, stroke 'Didn't even occur to me'
Glucose levels linked to maternal mortality even in non-diabetic women
Anti-obesity medications mitigate weight regain in RYGB surgery patients
DKOU 2020 abgesagt - Biermann Medizin
Aldosterone production is a common and unrecognized cause of high blood pressure
Social distancing is particularly hard on those with eating disorders, experts say
Local climate unlikely to drive the early COVID-19 pandemic
Studie zum Infektionsgeschehen an Schulen
How should I clean and store my face mask?
Blood flow recovers faster than brain in micro strokes
Chirurgie-Ausbildung mit Roboter und Virtueller Realität
New virus deaths in Spain fall to two-month low under 100
People with substance use disorders face greater challenges during the COVID-19 pandemic
The malaria parasite P. vivax can remain in the spleen upon expression of certain proteins

Leave a Reply

Your email address will not be published. Required fields are marked *

Next Post

Mental ill health 'substantial health concern' among police, finds international study

Fri May 22 , 2020
Credit: CC0 Public Domain Mental health issues among police officers are a “substantial health concern,” with around 1 in 4 potentially drinking at hazardous levels and around 1 in 7 meeting the criteria for post traumatic stress disorder and depression, finds a pooled data analysis of the available international evidence, […]