Do patients with lupus cerebritis merit long-term antiepileptic drug
treatment and has pulse cyclophosphamide a lesser incidence of side
effects in this respect than daily cyclophosphamide, specifically a lesser
incidence of haemorrhagic cystitis?
Cerebral lupus is treated with steroids and immunosuppression, e.g.
cyclophosphamide. Pulse cyclophosphamide does seem to be associated
with less haemorrhagic cystitis but it also seems to be less effective. (There
are no good controlled trials.) Antiepileptic treatment would only be used if
a flare-up in disease activity produces fits. Treatment would continue until
the disease is inactive when cautious withdrawal would be reasonable.