What is the significance of the Lisch nodules?

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What is the significance of the Lisch nodules?

Lisch nodules are melanocytic hamartomas that appear as well-defined, dome-shaped elevations projecting from the surface of the iris and are clear to yellow and brown. The incidence increases with age: at the age of 5 years only 22% have Lisch nodules

whereas, at the age of 20 years, 100% have them. Older patients who do not have Lisch nodules are also, therefore, unlikely to have neurofibromatosis 1. Lisch

nodules are an important tool in establishing the diagnosis of neurofibromatosis type I and in providing accurate genetic screening

(N Engl J Med 1991; 324: 1264).

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