New gene editing technique enables millions of genetic experiments to be performed simultaneously — ScienceDaily


[ad_1] Researchers have created a new gene editing tool called Retron Library Recombineering (RLR) that can generate up to millions of mutations simultaneously, and ‘barcodes’ mutant bacterial cells so that the entire pool can be screened at once. It can be used in contexts where CRISPR is toxic or not feasible, and results in better […]

Genetically modifying mosquitoes to express antimalarial genes and pass them on to their offspring is being tested as a new strategy to eliminate malaria — ScienceDaily


[ad_1] Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in eLife. The study is the latest in a series of steps toward using CRISPR-Cas9 gene-editing technology to make changes in mosquito […]

Katër ndodhi të jashtëzakonshme shkencore të 2020-s, të cilat ndoshta s’ i dini për shkak të virusit


[ad_1] Viti që lamë pas ishte një vit i trazuar për shkak të pandemisë. Megjithatë, nga një tjetër këndvështrim shkencor, ishte një vit përparimesh të jashtëzakonshme 1. Viti i kodit gjenetik Redaktimi i gjeneve është një nga dukuritë më të rëndësishme shkencore të vitit që lamë pas. Në tetor, për herë të parë në histori, […]

New immunotherapeutic approach takes aim at cancer’s enzyme shield


[ad_1] Credit: Brigham and Women’s Hospital Immunotherapies have transformed the landscape of cancer treatment by allowing physicians to alter or augment patients’ immune response to better attack malignant tumors. But some tumors—known as “cold tumors”—fly under the immune system’s radar. Checkpoint inhibitors, which are the basis of many immunotherapies, don’t work well against them. A […]

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells


[ad_1] Cancer cell during cell division. Credit: National Institutes of Health Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer […]

Erste hochskalierbare Methode zur Untersuchung der Proteinlevel und Proteinlokalisierungen in Zellen entwickelt


[ad_1] Forscher des CeMM haben eine hochskalierbare Methode entwickelt, die es erlaubt, Hunderte von Proteinen parallel zu untersuchen, um die Veränderungen ihrer Mengen und Lokalisierungen in der Zelle zu verfolgen. Diese neuartige Strategie kann beispielsweise verwendet werden, um die Auswirkungen von Wirkstoffkandidaten auf zahlreiche Proteine in der Zelle zu beobachten und stellt somit einen wesentlichen […]

Crispr Gene Editing Can Cause Unwanted Changes in Human Embryos, Study Finds


[ad_1] In 2017, a team of researchers led by Shoukhrat Mitalipov, a geneticist at Oregon Health and Science University in Portland, reported that human embryos carrying a mutation could be coaxed into this process without a synthetic template. The researchers generated embryos from a union between two cells: a sperm carrying a mutation that can […]

Cancer-fighting gene restrains ‘jumping genes’


[ad_1] This illustration depicts how retrotransposons are “handcuffed” by the tumor suppressor gene p53. But when p53 is lost, these mobile elements can erupt. Credit: Study authors Amanda Jones and Bhavana Tiwari. Artwork by Angela Diehl. About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT […]

Kohlmotte nutzt Pflanzenabwehrstoff als Signal für die Eiablage


[ad_1] Ein Forschungsteam konnte zeigen, dass Isothiocyanate, die Kreuzblütengewächse eigentlich zur Verteidigung gegen Fraßfeinde bilden, Kohlmottenweibchen als Duftsignale dienen, damit sie ihre Eier auf diesen Pflanzen ablegen können. Die Wissenschaftler identifizierten zwei Geruchsrezeptoren, deren einzige Aufgabe darin besteht, diese Duftstoffe aufzuspüren und den Weg zum idealen Eiablageplatz zu weisen. Kreuzblütengewächse, wie Kohl, Raps, Senf und […]

Study reveals restoration of retinal and visual function following gene therapy


[ad_1] A mutation in an inherited blindness mouse model abolishes the expression of RPE65, a key enzyme in a visual cycle, in the RPE cells. Base editing treatment can correct the mutation and restore functional RPE65 (green), thereby restoring vision in mice. Credit: Nature Biomedical Engineering A breakthrough study, led by researchers from the University […]

Single gene disorders not so simple after all


[ad_1] Credit: CC0 Public Domain Traditionally, geneticists divide disorders into “simple,” where a single gene mutation causes disease, or complex, where mutations in many genes contribute modest amounts. A new study suggests that the truth is somewhere in between. For many years, scientists studying patient genomes have gained glimpses of genetic “burden” or additional genetic […]

Fituesja e Nobelit në Kimi krijon testin që zbulon virusin në pesë minuta: Perspektiva e saj për COVID


[ad_1] Një grup studiuesish me bazë në Kaliforni kanë zhvilluar një test që zbulon virusin në pesë minuta, duke përdorur teknologjinë e ndryshimit të gjeneve si edhe aparatet fotografike të modifikuara në telefonat celularë, një metodë kjo që mund të ndihmojë shumë në luftimin e pandemisë Studimi, i udhëhequr nga Dr. Jennifer Doudna, një nga […]

US-French duo win Nobel Chemistry Prize for gene editing tool


[ad_1] Nobel Chemistry prize winners Emmanuelle Charpentier (L) and Jennifer Doudna of the United States Emmanuelle Charpentier of France and Jennifer Doudna of the US on Wednesday won the Nobel Chemistry Prize for the gene-editing technique known as the CRISPR-Cas9 DNA snipping “scissors”, the first time a Nobel science prize has gone to a women-only […]

A genetic variant that protects against Alzheimer’s disease promotes immune cell functions


[ad_1] Credit: Unsplash/CC0 Public Domain A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new […]