How meningitis-causing bacteria may sense fever to avoid immune killing — ScienceDaily


Researchers at Karolinska Institutet in Sweden have discovered a mechanism through which meningitis-causing bacteria can evade our immune system. In laboratory tests, they found that Streptococcus pneumoniae and Haemophilus influenzae respond to increasing temperatures by producing safeguards that keep them from getting killed. This may prime their defenses against our immune system and increase their […]

New gene editing technique enables millions of genetic experiments to be performed simultaneously — ScienceDaily


Researchers have created a new gene editing tool called Retron Library Recombineering (RLR) that can generate up to millions of mutations simultaneously, and ‘barcodes’ mutant bacterial cells so that the entire pool can be screened at once. It can be used in contexts where CRISPR is toxic or not feasible, and results in better editing […]

Diseases affect brain’s networks selectively, BrainMap analysis affirms — ScienceDaily


The brain possesses a complex architecture of functional networks as its information-processing machinery. Is the brain’s network architecture itself a target of disease? If so, which networks are associated with which diseases? What can this tell us about the underlying causes of brain disorders? Building on the extraordinary progress in neuroscience made over the past […]

A new perspective on the genomes of archaic humans — ScienceDaily


A genome by itself is like a recipe without a chef — full of important information, but in need of interpretation. So, even though we have sequenced genomes of our nearest extinct relatives — the Neanderthals and the Denisovans — there remain many unknowns regarding how differences in our genomes actually lead to differences in […]

Skin and bones repaired by bioprinting during surgery — ScienceDaily


Fixing traumatic injuries to the skin and bones of the face and skull is difficult because of the many layers of different types of tissues involved, but now, researchers have repaired such defects in a rat model using bioprinting during surgery, and their work may lead to faster and better methods of healing skin and […]

Neural implant monitors multiple brain areas at once, provides new neuroscience insights — ScienceDaily


How do different parts of the brain communicate with each other during learning and memory formation? A new study by researchers at the University of California San Diego takes a first step at answering this fundamental neuroscience question. The study was made possible by developing a neural implant that monitors the activity of different parts […]

Understanding molecular interactions might be a target of precision medicine — ScienceDaily


Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases. The role of several lncRNAs in anti-viral inflammatory response regulation has recently been reported. Considering their significant regulatory function in immune response, researchers from the Azrieli Faculty of Medicine of Bar-Ilan University sought to identify lncRNAs co-expressed with […]

Hepatitis C drugs combined with Remdesivir show strong effectiveness against COVID-19, study finds — ScienceDaily


A combination of remdesivir, a drug currently approved in the United States for treating COVID-19 patients, and repurposed drugs for hepatitis C virus (HCV) was 10 times more effective at inhibiting SARS-CoV-2, the virus that causes COVID-19. The combination therapy points a way toward a treatment for unvaccinated people who become infected, as well as […]

Research shows exposure to high temperatures can neutralize the virus, preventing it from infecting another human host — ScienceDaily


Arum Han, professor in the Department of Electrical and Computer Engineering at Texas A&M University, and his collaborators have designed an experimental system that shows exposure of SARS-CoV-2 to a very high temperature, even if applied for less than a second, can be sufficient to neutralize the virus so that it can no longer infect […]

Stress slows the immune response in sick mice — ScienceDaily


The neurotransmitter noradrenaline, which plays a key role in the fight-or-flight stress response, impairs immune responses by inhibiting the movements of various white blood cells in different tissues, researchers report April 28th in the journal Immunity. The fast and transient effect occurred in mice with infections and cancer, but for now, it’s unclear whether the […]

In cells and mice, tiny molecules stop bacteria from hijacking cells — ScienceDaily


Tiny molecules called nanobodies, which can be designed to mimic antibody structures and functions, may be the key to blocking a tick-borne bacterial infection that remains out of reach of almost all antibiotics, new research suggests. The infection is called human monocytic ehrlichiosis, and is one of the most prevalent and potentially life-threatening tick-borne diseases […]

Certain gut microbes make mosquitoes more prone to carry malaria parasite — ScienceDaily


Dietary sugars and gut microbes play a key role in promoting malaria parasite infection in mosquitoes. Researchers in China have uncovered evidence that mosquitoes fed a sugar diet show an increased abundance of the bacterial species Asaia bogorensis, which enhances parasite infection by raising the gut pH level. The study appears April 20 in the […]

Stress test finds cracks in the resistance of harmful hospital bugs — ScienceDaily


Research has identified critical factors that enable dangerous bacteria to spread disease by surviving on surfaces in hospitals and kitchens. The study into the mechanisms which enable the opportunistic human pathogen Pseudomonas aeruginosa to survive on surfaces, could lead to new ways of targeting harmful bacteria. To survive outside their host, pathogenic bacteria must withstand […]

New study parses out when customers may feel undue persuasion and reduce their willingness to purchase a product — ScienceDaily


Product marketers should be clear in their messaging to avoid customer skepticism that makes them feel duped, according to University of Oregon research. At issue in a new study, published in the Journal of Business Research, was a social-cognitive construct called theory of mind, which considers how well people assess the mental states and apparent […]

New ways to classify and study spinal cord neurons could inform therapies for illness or injury — ScienceDaily


Spinal cord nerve cells branching through the body resemble trees with limbs fanning out in every direction. But this image can also be used to tell the story of how these neurons, their jobs becoming more specialized over time, arose through developmental and evolutionary history. Salk researchers have, for the first time, traced the development […]

Force transmission between cells orchestrates collective cellular motion — ScienceDaily


How do the billions of cells communicate in order to perform tasks? The cells exert force on their environment through movement — and in doing so, they communicate. They work as a group in order to infiltrate their environment, perform wound healing and the like. They sense the stiffness or softness of their surroundings and […]

A study in cells and mice finds compound works with fewer side effects than opioids — ScienceDaily


Fentanyl, oxycodone, morphine — these substances are familiar to many as a source of both pain relief and the cause of a painful epidemic of addiction and death. Scientists have attempted for years to balance the potent pain-relieving properties of opioids with their numerous negative side effects — with mostly mixed results. Work by John […]

Scientists generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos — ScienceDaily


In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos. The use of animal embryos is also subject to restrictions rooted in ethical considerations. To overcome these limitations, scientists have been trying to recreate early embryos […]

Ankle exoskeleton enables faster walking — ScienceDaily


Being unable to walk quickly can be frustrating and problematic, but it is a common issue, especially as people age. Noting the pervasiveness of slower-than-desired walking, engineers at Stanford University have tested how well a prototype exoskeleton system they have developed — which attaches around the shin and into a running shoe — increased the […]

Medics at Iowa state prison gave 77 inmates up to SIX TIMES the normal dose of the Pfizer vaccine 


Medics at an Iowa state prison gave 77 inmates up to SIX TIMES the normal dose of the Pfizer coronavirus vaccine Medical staff gave 77 inmates at the Iowa State Penitentiary were given the wrong dose of the Pfizer-BioNTech coronavirus vaccine Patients were given 3 mL doses, which is six times higher than the dose of […]

Illuminating invisible bloody fingerprints with a fluorescent polymer — ScienceDaily


Careful criminals usually clean a scene, wiping away visible blood and fingerprints. However, prints made with trace amounts of blood, invisible to the naked eye, could remain. Dyes can detect these hidden prints, but the dyes don’t work well on certain surfaces. Now, researchers reporting in ACS Applied Materials & Interfaces have developed a fluorescent […]

New approach to gene therapy can correct any disease-causing mutation within a gene — ScienceDaily


A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases. The method, developed and tested in mice and human tissue cultures by researchers at Penn […]

Researchers highlight need for public education on impact of algorithms — ScienceDaily


In a new series of experiments, artificial intelligence (A.I.) algorithms were able to influence people’s preferences for fictitious political candidates or potential romantic partners, depending on whether recommendations were explicit or covert. Ujué Agudo and Helena Matute of Universidad de Deusto in Bilbao, Spain, present these findings in the open-access journal PLOS ONE on April […]

‘Information theory’ recruited to help scientists find cancer genes — ScienceDaily


Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL). ALL is the most […]

The immune link between a leaky blood-brain barrier and schizophrenia — ScienceDaily


Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation — at least when all is functioning normally. That may not be the case in people with schizophrenia and other mental disorders, suggest new findings from a team led by researchers from […]

Repurposed drug works by building cells’ skeleton and transportation network — ScienceDaily


A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons’ cellular skeletons. The supplement betaine was first isolated from sugar beets and is often […]

The impact of gun muzzle gases on blood backspatter captured, implications for forensic analysis of bloodstain patterns — ScienceDaily


Forensic science includes the analysis of blood backspatter involved in gunshot wounds, but scientific questions about the detailed role of fluids in these situations remained unresolved. To search for answers about how blood droplets from a gunshot wound can reverse direction while in flight, University of Illinois at Chicago and Iowa State University researchers explored […]

Chickens and pigs with integrated genetic scissors — ScienceDaily


Researchers at the TUM have demonstrated a way to efficiently study molecular mechanisms of disease resistance or biomedical issues in farm animals. Researchers are now able to introduce specific gene mutations into a desired organ or even correct existing genes without creating new animal models for each target gene. This reduces the number of animals […]

Our attention is captured by eye-glance — ScienceDaily


Eyes play an important role in social communication by expressing the intentions of our interlocutors, and even more so in times of pandemic when half of the face is hidden. But is this eye contact automatic and rapid? Is it based on a priority attentional reaction or, on the contrary, on a particular emotional reaction? […]

Study explores flushing power to test risk of COVID-19 transmission — ScienceDaily


Flushing a toilet can generate large quantities of microbe-containing aerosols depending on the design, water pressure or flushing power of the toilet. A variety of pathogens are usually found in stagnant water as well as in urine, feces and vomit. When dispersed widely through aerosolization, these pathogens can cause Ebola, norovirus that results in violent […]

Targeted chemotherapy of glioblastoma spheroids with an iontronic pump — ScienceDaily


Despite surgery and subsequent treatment with chemotherapy and radiation, the majority of patients experience recurrence of malignant brain tumours. Researchers at Linköping University, Sweden, and the Medical University of Graz, Austria, have shown in cells in culture that an ion pump can deliver drugs more accurately, which gives less severe adverse effects in chemotherapy. The […]

The new model may have applications for studying and predicting a range of dynamical systems — ScienceDaily


The dynamics of the neural activity of a mouse brain behave in a peculiar, unexpected way that can be theoretically modeled without any fine tuning, suggests a new paper by physicists at Emory University. Physical Review Letters published the research, which adds to the evidence that theoretical physics frameworks may aid in the understanding of […]

Novel genetic mitochondrial disorder discovered — ScienceDaily


The list of known genetic mitochondrial disorders is ever-growing, and ongoing research continues to identify new disorders in this category. In an article recently published in Brain, a Japanese-European team of scientists, including researchers from Fujita Health University, describe mutations in the LIG3 gene, which plays a crucial role in mitochondrial DNA replication. These mutations […]

A 3D structure reveals how a unique molecular switch in our brain causes us to feel full — and may help develop improved anti-obesity drugs — ScienceDaily


Being constantly hungry, no matter how much you eat — that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University […]

Tiny implantable tool for light-sheet imaging of brain activity — ScienceDaily


Tools that allow neuroscientists to record and quantify functional activity within the living brain are in great demand. Traditionally, researchers have used techniques such as functional magnetic resonance imaging, but this method cannot record neural activity with high spatial resolution or in moving subjects. In recent years, a technology called optogenetics has shown considerable success […]

Metformin inhibits disease progression in non-diabetic chronic kidney disease (ND-CKD) — ScienceDaily


Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin’s mechanism is different from existing therapeutics which only treat symptoms, […]

MK-4482 shows potential to prevent and treat SARS-CoV-2 infection — ScienceDaily


The experimental antiviral drug MK-4482 significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection, according to a new study from National Institutes of Health scientists. SARS-CoV-2 is the virus that causes COVID-19. MK-4482, delivered orally, is now in human clinical trials. Remdesivir, an antiviral drug already approved […]

Scientists identify human genes that fight infection — ScienceDaily


Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body’s […]

Plasma device designed for consumers can quickly disinfect surfaces — ScienceDaily


The COVID-19 pandemic has cast a harsh light on the urgent need for quick and easy techniques to sanitize and disinfect everyday high-touch objects such as doorknobs, pens, pencils, and personal protective gear worn to keep infections from spreading. Now scientists at the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory and the New […]

New CRISPR technology offers unrivaled control of epigenetic inheritance — ScienceDaily


Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome — proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. In a paper published April 9, 2021, in the journal Cell, […]

New study explains why you should look at your food before casting judgment — ScienceDaily


The order in which your senses interact with food has a tremendous impact on how much you like it. That’s the premise of a new study led by the University of South Florida (USF). The findings published in the Journal of Consumer Psychology show that food tastes better if you see it before smelling it. […]

New measure to predict stress resilience — ScienceDaily


Researchers at the University of Zurich show that increased sensitivity in a specific region of the brain contributes to the development of anxiety and depression in response to real-life stress. Their study establishes an objective neurobiological measure for stress resilience in humans. Some people don’t seem to be too bothered when it comes to handling […]

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos — ScienceDaily


The DNA molecule is not naked in the nucleus. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This 3D spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by […]

Scientists generate human-monkey chimeric embryos — ScienceDaily


Investigators in China and the United States have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time — up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications […]

Get your head in the game — One gene’s role in cranial development — ScienceDaily


Researchers from Tokyo Medical and Dental University (TMDU) use genetic engineering in mice to further understand how cell fate is determined in the head Tokyo, Japan — Mammalian embryonic development is an extremely complex and precise process. Specific molecular events act as cues that tell cells in the embryo where to move and what type […]

Lipid research may help solve COVID-19 vaccine challenges — ScienceDaily


New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain COVID-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online April 13 in Nature Communications, the researchers demonstrate a new, inexpensive […]

Nanomaterials strategically activate the immune system to fight inflammation as effectively as current standard therapeutics — ScienceDaily


Biomedical engineers at Duke University have developed a self-assembling nanomaterial that can help limit damage caused by inflammatory diseases by activating key cells in the immune system. In mouse models of psoriasis, the nanofiber-based drug has been shown to mitigate damaging inflammation as effectively as a gold-standard therapy. One of the hallmarks of inflammatory diseases, […]

Trendy ‘mindfulness’ programmes can make you more SELFISH, study finds


Trendy ‘mindfulness’ programmes can make you more SELFISH: Meditation increases egotistical behaviours for independent people, study finds Researchers studied how independence altered the response to mindfulness   The practice triggers increased selfishness in independent people It has the opposite effect on team players and leads to more altruistic behaviour   By Joe Pinkstone For Mailonline Published: 07:23 EDT, 15 April […]

Genetically modifying mosquitoes to express antimalarial genes and pass them on to their offspring is being tested as a new strategy to eliminate malaria — ScienceDaily


Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in eLife. The study is the latest in a series of steps toward using CRISPR-Cas9 gene-editing technology to make changes in mosquito genes […]

Scientists develop biofuel cells that can power wearable electronics purely by using human sweat — ScienceDaily


Wearable electronic devices and biosensors are great tools for health monitoring, but it has been difficult to find convenient power sources for them. Now, a group of scientists has successfully developed and tested a wearable biofuel cell array that generates electric power from the lactate in the wearer’s sweat, opening doors to electronic health monitoring […]

Amoeba biology reveals potential treatment target for lung disease — ScienceDaily


In a series of experiments that began with amoebas — single-celled organisms that extend podlike appendages to move around — Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment. “Physician-scientists […]

Joyful screams perceived more strongly than screams of fear or anger — ScienceDaily


The human scream signals more than fear of imminent danger or entanglement in social conflicts. Screaming can also express joy or excitement. For the first time, researchers have demonstrated that non-alarming screams are even perceived and processed by the brain more efficiently than their alarming counterparts. Screaming can save lives. Non-human primates and other mammalian […]

Gene therapy shows promise in treating rare eye disease in mice — ScienceDaily


A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife. The findings suggest that this therapy, whether used alone or in combination with other gene therapies that boost eye health, may offer a […]

165 new cancer genes identified with the help of machine learning — ScienceDaily


A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with “Artificial Intelligence” and identified numerous cancer genes. This opens up new perspectives for targeted cancer therapy in personalized medicine and for the development […]

UMD-led study warns cascading effects of salts require coordinated management and regulation to avoid contaminating natural resources — ScienceDaily


When winter storms threaten to make travel dangerous, people often turn to salt, spreading it liberally over highways, streets and sidewalks to melt snow and ice. Road salt is an important tool for safety, because many thousands of people die or are injured every year due to weather related accidents. But a new study led […]

Vascular smooth muscle-derived Trpv1+ progenitors have found to be a source of cold-induced — ScienceDaily


A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism on 12 March 2021, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive […]

Using genetics, researchers identify potential drugs for early treatment of COVID-19 — ScienceDaily


A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine in March 2021. Based on their analyses, the researchers are calling for prioritizing clinical trials of drugs targeting the proteins IFNAR2 […]

Scientists say human embryos could be grown in a test tube for FIVE WEEKS after mice develop in jars


Human embryos could be the next test subjects of a groundbreaking study that kept mouse embryos alive outside of the womb that developed a heart, stomach, head and limbs in six days. A team of Israeli scientists grew filled small jars with nutrients inside that were placed on rotating roller and pumped each with a pressurized […]

The tuberculosis pathogen releases its toxin by a novel protein transport system — ScienceDaily


Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the founding member of a novel class of previously unrecognized toxins present in more than 600 bacterial and fungal species, as determined by protein sequence similarity. The toxin is […]

Blocking a protein could help overcome cancer resistance to PARP inhibitors — ScienceDaily


Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumour sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers. Some cancers, including certain breast, ovarian and prostate tumours, are caused by a […]

Health minister defends use of controversial lateral flow tests in No10’s new twice-a-week plan


Experts today lined up to attack Number 10 for a bold new plan to screen the entire nation for coronavirus twice a week using lateral flow tests. Critics of the controversial kits – which offer results in half an hour – called the scheme ‘beyond reckless’, a ‘public health disaster’ and a ‘scandalous’ waste of […]

Toward a reliable oral treatment for sickle cell disease — ScienceDaily


For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, researchers will describe the discovery of a small molecule with the potential to address the root cause of sickle […]

A new study suggests that when men and women express the same amount of pain, women’s pain is considered less intense based on gender stereotypes. — ScienceDaily


In a recent study published by the Journal of Pain, co-authored by Elizabeth Losin, assistant professor of psychology and director of the Social and Cultural Neuroscience lab at the University of Miami, researchers found that a patient’s pain responses may be perceived differently by others based on their gender. According to “Gender biases in estimation […]

An amyloid link between Parkinson’s disease and melanoma — ScienceDaily


On the surface, Parkinson’s disease — a neurodegenerative disorder — and melanoma — a type of skin cancer — do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson’s disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link […]

Why 2020 was the year of marvellous medicine


A year ago, the world was in the grip of a deadly and, seemingly, unstoppable virus and the UK went into its first lockdown.  Since then, vaccines and life-saving drugs to counter Covid have been the focus of international attention.  But the past year has also seen major developments in treatments for cancer, diabetes, multiple […]

Researchers explain the human tendency to make change through addition — ScienceDaily


In a new paper featured on the cover of Nature, University of Virginia researchers explain why people rarely look at a situation, object or idea that needs improving — in all kinds of contexts — and think to remove something as a solution. Instead, we almost always add some element, whether it helps or not. […]

Findings lead to the development of therapeutic strategies to overcome it — ScienceDaily


A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. In a new article published […]

COVID-19 causes ‘unexpected’ cellular response in the lungs, research finds — ScienceDaily


New insights into the immune response to SARS-CoV-2 infections could bring better treatments for COVID-19 cases. An international team of researchers unexpectedly found that a biochemical pathway, known as the immune complement system, is triggered in lung cells by the virus, which might explain why the disease is so difficult to treat. The research is […]

A new agent for brain diseases: mRNA — ScienceDaily


Researchers from Tokyo Medical and Dental University (TMDU) demonstrate an mRNA delivery system that effectively produces BDNF protein in rat brain to protect neurons from ischemia Tokyo — A lack of oxygen to brain tissue — known as ischemia — leads to the death of neurons, which results in stroke. Despite considerable research, there are […]

Study used eye-trackers to see how people selected snack foods — ScienceDaily


It’s one thing to decide among two or three snacks available at a friend’s house. But what do people do when they’re faced with a vending machine offering 36 different options? A new study using eye-tracking technology suggests that the amount of time people spend looking at individual items may actually help them decide. Findings […]

Society is not ready to make human brains — ScienceDaily


Stem cell research has allowed medicine to go places that were once science fiction. Using stem cells, scientists have manufactured heart cells, brain cells and other cell types that they are now transplanting into patients as a form of cell therapy. Eventually, the field anticipates the same will be possible with organs. A new paper […]

Biologists create better method to culture cells for testing drug toxicity — ScienceDaily


When a new drug is being developed, the first question is, “Does it work?” The second question is, “Does it do harm?” No matter how effective a therapy is, if it harms the patient in the process, it has little value. Doctoral student Robert Skolik and Associate Professor Michael Menze, Ph.D., in the Department of […]

Q&A: How the scars of Flint’s water crisis shake city’s faith in Covid-19 vaccine


In 2014, the state’s public officials assured the residents that their water was safe to drink. It wasn’t. Now, with the coronavirus vaccine rolling out across the country, some Flint residents are wondering whether or not it’s safe to take. Hesitancy is particularly high in some Black communities, which have a history of being discriminated […]

CNN exclusive: A solar panel in space is collecting energy that could one day be beamed to anywhere on Earth


The panel — known as a Photovoltaic Radiofrequency Antenna Module (PRAM) — was first launched in May 2020, attached to the Pentagon’s X-37B unmanned drone, to harness light from the sun to covert to electricity. The drone is looping Earth every 90 minutes. The panel is designed to make best use of the light in […]

This 29-year-old cancer survivor is set to be the youngest American ever in space


“I remember laughing,” Arceneaux told CNN Business. “And then, I just said — ‘Yes! Yes, like, put my name down.’” Arceneaux will be one of four crew members on Inspiration 4, the first spaceflight to take a group composed entirely of civilians — not professional astronauts — on a multi-day journey to orbit the Earth. […]

30% of people with Covid-19 continue to have symptoms up to 9 months after infection, study finds


People of color have been vastly underrepresented in US-based vaccine trials for the last decade, according to a new study released Friday by researchers at Fred Hutchinson Cancer Research Center, Harvard, Emory and other institutions. The study, which examined data from 230 vaccine trials with nearly 220,00 participants, found that White people made up the […]

The Swiss Cheese Model of Pandemic Defense


Q. What have we learned since March? A. Distance is the most effective intervention; the virus doesn’t have legs, so if you are physically distant from people, you avoid direct contact and droplets. Then you have to consider inside spaces, which are especially in play during winter or in hotter countries during summer: the bus, […]

Researchers discover new particle in the blood of septic patients


This timelapse image shows the appearanc of an ENDS and how it curls over time. Credit: Alex Marki, Ph.D., Ley Laboratory, La Jolla Institute for Immunology Researchers at La Jolla Institute for Immunology (LJI) have found that people with sepsis have never-before-seen particles in their blood. The scientists are the first to show that these […]

Researchers define immune system’s requirements for protection against COVID-19


Colorized scanning electron micrograph of a cell (blue) heavily infected with SARS-CoV-2 virus particles (red), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Since the novel coronavirus emerged at the end of last year, scientists around the world—including Beth Israel Deaconess Medical Center […]

Could a Blood Test Show if a Covid-19 Vaccine Works?


A new study in monkeys suggests that a blood test could predict the effectiveness of a Covid-19 vaccine — and perhaps speed up the clinical trials needed to get a working vaccine to billions of people around the world. The study, published on Friday in Nature, reveals telltale blood markers that predict whether a monkey’s immune […]

Mimicking effect of exercise with gene therapy


Gene therapy research can benefit people who have had accidents, who are in wheelchairs, or who have diseases that prevent the possibility of physical expression – but also people who generally respond poorly to training. Credit: Scanpix / Shutterstock It sounds too good to be true—and it is. But Jose Bianco Moreira and the CERG […]

‘Nobody Sees Us’: Testing-Lab Workers Strain Under Demand


In March, April Abbott dragged a hospital bed into her office at Deaconess Hospital in Evansville, Ind. In the nine months since, she has slept in it a half-dozen times while working overnight in her clinical microbiology laboratory, where a team of some 40 scientists toils around the clock running coronavirus tests. These all-night stints […]

Many Trial Volunteers Got Placebo Vaccines. Do They Now Deserve the Real Ones?


In October, Judith Munz and her husband, Scott Petersen, volunteered for a coronavirus vaccine trial. At a clinic near their home in Phoenix, each got a jab in the arm. Dr. Petersen, a retired physician, became a little fatigued after his shot, and developed redness and swelling on his arm. But Ms. Munz, a social […]

Moderna to Begin Testing Its Coronavirus Vaccine in Children


The drugmaker Moderna said on Wednesday that it would soon begin testing its coronavirus vaccine in children ages 12 through 17. The study, listed Wednesday on the website clinicaltrials.gov, is to include 3,000 children, with half receiving two shots of vaccine four weeks apart, and half getting placebo shots of salt water. But the posting […]

Long-Term-Care Residents and Health Workers Should Get Vaccine First, C.D.C. Panel Says


“So very quickly, we start having more than 150 million doses a month in March, April, May,” he added. He and other federal officials have said that the general public is likely to be able to be vaccinated by May or June. The Road to a Coronavirus Vaccine Words to Know About Vaccines Confused by […]

Who Will Get the Coronavirus Vaccine First?


After months of deliberation and debate, a panel of independent experts advising the Centers for Disease Control and Prevention is set to decide on Tuesday which Americans it will recommend to get the coronavirus vaccine first, while supply is still short. The panel, the Advisory Committee on Immunization Practices, will vote in a public meeting […]

London A.I. Lab Claims Breakthrough That Could Accelerate Drug Discovery


Some scientists spend their lives trying to pinpoint the shape of tiny proteins in the human body. Proteins are the microscopic mechanisms that drive the behavior of viruses, bacteria, the human body and all living things. They begin as strings of chemical compounds, before twisting and folding into three-dimensional shapes that define what they can […]

Prisons Are Covid-19 Hotbeds. When Should Inmates Get the Vaccine?


The United States holds some 2.3 million individuals in prisons, jails and other detention centers, incarcerating more people per capita than any other nation. That includes nearly 500,000 people who have not been convicted of a crime and are awaiting trials, according to the Prison Policy Initiative. (Some jails have taken steps to reduce overcrowding […]

Moderna Applies for Emergency F.D.A. Approval for Its Coronavirus Vaccine


The drugmaker Moderna said it would apply on Monday to the Food and Drug Administration to authorize its coronavirus vaccine for emergency use. The first injections may be given as early as Dec. 21 if the process goes smoothly and approval is granted, Stéphane Bancel, the company’s chief executive, said in an interview. Moderna’s application […]

‘Turncoat’ macrophages in the tumor ‘micro-environment’ underlie breast cancer progression


Credit: CC0 Public Domain New research that is examining the “tumor microenvironment” reveals not only how macrophages can become extraordinary turncoats but also how they can actively support tumor growth and metastatic progression in certain forms of breast cancer. The tumor microenvironment—or TME—refers to the region encompassing a tumor, an area entangled with blood vessels […]

Immune responses during embryo development could increase risk of schizophrenia


Human Embryo. Credit: Ed Uthman, MD/Wikipedia Past research has often highlighted the effects that immune activation in pregnant women can have on the development of human embryos, for instance increasing the risk of a child developing psychiatric disorders later in life. The neural mechanisms underpinning these effects, however, remain largely unclear. Researchers at New York […]

The Coronavirus Won’t Stop Evolving When the Vaccine Arrives


In a 1988 essay on pandemics Joshua Lederberg, Nobel laureate and president of The Rockefeller University, reminded the medical community that when it comes to infectious disease, the laws of Darwin are as important as the vaccines of Pasteur. As medicine battles bacteria and viruses, those organisms continue to undergo mutations and evolve new characteristics. […]

Embryonic stem cells have their own strategy for protecting chromosome ends


TRF2-deficient mouse embryonic stem cells (mESCs) have normal, unfused chromosomes, whereas differentiated, genetically identical cells (differentiated fibroblast-like cells, or FLICs) have massive levels of telomere fusions. These images show DNA in red and telomeres in green. Credit: Eros Lazzerini Denchi According to new research from CCR scientists, embryonic stem cells have a unique way of […]

Study is the first to link microbiota to dynamics of the human immune system


(From left) Researchers Emily Fontana, Luigi Amoretti, Joao Xavier, Roberta Wright, and Jonas Schluter in the lab. Credit: Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center researchers have uncovered an important finding about the relationship between the microbiota and the immune system, showing for the first time that the concentration of different types […]

After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine


Bigger problems soon surfaced. An AstraZeneca executive told Reuters on Monday that the company had not intended for any participants to receive the half dose. British researchers running the trial there had meant to give the full dose initially to volunteers, but a miscalculation meant they were mistakenly given only a half dose. The executive, […]

Early Coronavirus Mutation Made It Harder to Stop, Evidence Suggests


As the coronavirus swept across the world, it picked up random alterations to its genetic sequence. Like meaningless typos in a script, most of those mutations made no difference in how the virus behaved. But one mutation near the beginning of the pandemic did make a difference, multiple new findings suggest, helping the virus spread […]

Early, late stages of degenerative diseases are distinct, study shows


Based on thousands of experiments over more than a decade, Rice University biochemists Michael Stern and James McNew believe degenerative diseases as varied as Alzheimer’s, Parkinson’s and muscle atrophy occur in two phases (green and red) marked by distinct alterations in the activity of the signaling pathway proteins TOR, AMPK, Foxo and JNK. In the […]

Antibodies Good. Machine-Made Molecules Better?


The coronavirus might be new, but nature long ago gave humans the tools to recognize it, at least on a microscopic scale: antibodies, Y-shaped immune proteins that can latch onto pathogens and block them from infiltrating cells. Millions of years of evolution have honed these proteins into the disease-fighting weapons they are today. But in […]

Scientists: How Has the Pandemic Changed Your Work?


Over the past year, the coronavirus pandemic has underscored for the entire world the value of science — not only for tracking the spread of a deadly virus and developing ways to stop it, but also for providing a rational method for understanding a frightening unknown. For some scientists, the pandemic has come with silver […]

How rotavirus causes severe gastrointestinal disease


Transmission electron micrograph (TEM) of intact rotavirus particles. Credit: CDC Rotavirus is a major cause of diarrhea and vomiting, especially in children, that results in approximately 128,000 deaths annually. The virus triggers the disease by infecting enterocyte cells in the small intestine, but only a fraction of the susceptible cells has the virus. In the […]