HEALTH NOTES: Women still take sun-tanning risk


HEALTH NOTES: One in ten women admits risking deadly skin cancer by excessive holiday sunbathing By Mail on Sunday Reporter Published: 17:02 EDT, 1 May 2021 | Updated: 17:14 EDT, 1 May 2021 One woman in ten admits to sunbathing for five hours a day on two-week holidays – dramatically increasing the risk of deadly […]

Blind patients hope to gain vision in medical first of CRISPR editing DNA inside their bodies


In a world first, scientists are using the controversial CRISPR technology to edit genes while the DNA is still inside a person’s body. Typically, the tool –  used to treat conditions like sickle cell disease – removes cells from the body, edits out the mutated parts and then reinserts them, along with instructions to create […]

Short-term spikes in air pollution ‘may speed up brain decline in older men’


CAUSE CHILDREN TO HAVE A LOW IQ: Researchers at the University of California, San Francisco, found in May 2019 that children born to mothers who live in polluted areas have an IQ that is up to seven points lower than those living in places with cleaner air. CAUSE CHILDREN TO HAVE POORER MEMORY: Researchers at the […]

PROFESSOR ROY TAYLOR explains the science behind type 2 diabetes


Barely a day goes by without type 2 diabetes hitting the headlines. Last week alone there were two major stories about the condition.  A study from French researchers showed that if you develop type 2 in middle age, it doubles your risk of getting dementia by the age of 70. Another study, which looked at […]

Stem cells create early human embryo structure in advance for fertility research — ScienceDaily


Exeter scientists have discovered a simple, efficient way to recreate the early structure of the human embryo from stem cells in the laboratory. The new approach unlocks news ways of studying human fertility and reproduction. Stem cells have the ability to turn into different types of cell. Now, in research published in Cell Stem Cell […]

Process for eliminating unneeded cells may also protect against cancer — ScienceDaily


For all animals, eliminating some cells is a necessary part of embryonic development. Living cells are also naturally sloughed off in mature tissues; for example, the lining of the intestine turns over every few days. One way that organisms get rid of unneeded cells is through a process called extrusion, which allows cells to be […]

C. albicans’ ability to shift forms can help it cause dangerous infections, and a study suggests that a protein called Sir2 aids this transition — ScienceDaily


You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast or propagate in an elongated form called hypha, consisting of thread-like filaments. This dual nature can help the pathogen survive in the body, where it can cause disease, including dangerous hospital-acquired infections. But how does […]

Novel non-coding RNAs regulating blood vessel formation — ScienceDaily


Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis. The study, conducted by the research groups of Associate Professor Minna Kaikkonen-Määttä and Academy Professor Seppo Ylä-Herttuala, provides a better understanding of the complex […]

The origin of reproductive organs — ScienceDaily


Early in human development, during the first trimester of gestation, a fetus may have XX or XY chromosomes that indicate its sex. Yet at this stage a mass of cells known as the bipotential gonad that ultimately develops into either ovaries or testes has yet to commit to its final destiny. While researchers had studied […]

Researchers speed identification of DNA regions that regulate gene expression — ScienceDaily


St. Jude Children’s Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics. Researchers used the system to identify dozens of DNA regulatory elements that act together […]

Study compares epigenetic modifications to DNA in the cerebellum of humans, chimpanzees and monkeys — ScienceDaily


The cerebellum — a part of the brain once recognized mainly for its role in coordinating movement — underwent evolutionary changes that may have contributed to human culture, language and tool use. This new finding appears in a study by Elaine Guevara of Duke University and colleagues, published May 6th in the journal PLOS Genetics. […]

Researchers’ catalog of airway cell types could reveal targets for future genetic therapies — ScienceDaily


A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis. The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of […]

Why do some neurons degenerate and die in Alzheimer’s disease, but not others? — ScienceDaily


In the brain of a person with Alzheimer’s disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among those subtypes — mysteriously — some perish and some do not. Researchers at Gladstone Institutes […]

Researchers use ultrasound to develop delivery system for potent RNA drugs — ScienceDaily


RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality. This rapidly expanding class of therapeutics are cost-effective, fairly easy to manufacture, and able to go where no drug has gone before, reaching previously undruggable pathways. Mostly. So far, these promising drugs haven’t been very useful […]

Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels — ScienceDaily


Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs) — clusters of dilated blood vessels in the brain — can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing anticancer […]

Multi-drug resistant infection about to evolve within cystic fibrosis patients — ScienceDaily


Scientists have been able to track how a multi-drug resistant organism is able to evolve and spread widely among cystic fibrosis patients — showing that it can evolve rapidly within an individual during chronic infection. The researchers say their findings highlight the need to treat patients with Mycobacterium abscessus infection immediately, counter to current medical […]

New gene editing technique enables millions of genetic experiments to be performed simultaneously — ScienceDaily


Researchers have created a new gene editing tool called Retron Library Recombineering (RLR) that can generate up to millions of mutations simultaneously, and ‘barcodes’ mutant bacterial cells so that the entire pool can be screened at once. It can be used in contexts where CRISPR is toxic or not feasible, and results in better editing […]

Connecting genetic variants to changes in expression levels to understand immune-mediated diseases — ScienceDaily


Researchers in Japan have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. This resource will allow experts to more deeply understand how immune disorders develop and plan future drug discovery projects. Scientists also hope this atlas of immune-related genome data may eventually be applied to investigations of infectious diseases like COVID-19. “To understand […]

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer — ScienceDaily


In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology, […]

Covid-19 UK: More than half of positive rapid tests at schools were false, data reveals


Lateral flow tests are only accurate at diagnosing coronavirus when administered by trained professionals, studies have repeatedly shown.  The tests, which give results in as little as 15 minutes, use swabs of the nose or throat. Samples are then mixed in a testing liquid and put into a plastic cassette which can detect the presence […]

New urine test could detect aggressive form of prostate cancer missed by as many as 1 in 5 scans 


New urine test could detect aggressive form of prostate cancer often missed by as many as one in five diagnostic scans The University of Michigan Rogel Cancer Center has developed a new test called Urine Prostate Seq test (UPSeq) It analyzes 15 specific strands of RNA together and looks for specific genes that are ‘overexpressed’ […]

A new perspective on the genomes of archaic humans — ScienceDaily


A genome by itself is like a recipe without a chef — full of important information, but in need of interpretation. So, even though we have sequenced genomes of our nearest extinct relatives — the Neanderthals and the Denisovans — there remain many unknowns regarding how differences in our genomes actually lead to differences in […]

How your tears may soon help save your life


Here’s a good reason to start crying with happiness: your tears could soon save your life by providing an early warning of cancer, diabetes and autoimmune disease. In future, they may even predict your risk of developing Alzheimer’s. And tears are not the only bodily secretions that are being used in a new generation of […]

SARS-CoV-2 curtails immune response in the gut — ScienceDaily


In an effort to determine the potential for COVID-19 to begin in a person’s gut, and to better understand how human cells respond to SARS-CoV-2, the scientists used human intestinal cells to create organoids — 3D tissue cultures derived from human cells, which mimic the tissue or organ from which the cells originate. Their conclusions, […]

Mass Covid testing scheme could lead to spike in transmission, experts say


Lateral flow tests are only accurate at diagnosing coronavirus when administered by trained professionals, studies have repeatedly shown.  The tests, which give results in as little as 15 minutes, use swabs of the nose or throat. Samples are then mixed in a testing liquid and put into a plastic cassette which can detect the presence […]

New method preserves viable fruit fly embryos in liquid nitrogen — ScienceDaily


Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster) — which is crucial to genetics research and critical to scientific breakthroughs benefiting human health — has not been available. “To keep alive the ever-increasing […]

Understanding molecular interactions might be a target of precision medicine — ScienceDaily


Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases. The role of several lncRNAs in anti-viral inflammatory response regulation has recently been reported. Considering their significant regulatory function in immune response, researchers from the Azrieli Faculty of Medicine of Bar-Ilan University sought to identify lncRNAs co-expressed with […]

Doctors call on the US to send its stockpile of AstraZeneca vaccines to crisis-hit India NOW


Global health experts are calling on the U.S. government to send its stockpile of AstraZeneca-University of Oxford coronavirus vaccines to India immediately as health officials say they don’t anticipate using any of the doses. During a news briefing on Tuesday, Andy Slavitt, the White House senior COVID-19 advisor, addressed a report stating that the country […]

Women’s fertility may decline with age due to impaired RNA levels — ScienceDaily


Age may adversely affect women’s fertility by impairing levels of RNA molecules which in turn alter the function of genes involved in key biological pathways during the final maturation stage of a human egg cell, according to the findings of a new study published today in the journal Aging Cell. Researchers from the Centre for […]

CDC committee updates recommendations on use of the J&J Covid vaccine after pause is lifted


Johnson & Johnson‘s coronavirus vaccine will now include a warning that rare blood clotting events might occur after the shot is administering, primarily among women under age 50. Two weeks ago, the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA) suggested clinicians stop using the shot after more […]

Impaired drainage also may play a role in Alzheimer’s in people — ScienceDaily


Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from the brain, according to a […]

Antimicrobial resistant bacteria getting into watershed — ScienceDaily


It’s well established that infectious disease is the greatest threat to the endangered chimpanzees made famous by the field studies of Jane Goodall at Gombe National Park in Tanzania. Now, new research led by scientists at Emory University shows that nearly half of the fecal samples from wild chimpanzees contain bacteria that is resistant to […]

‘Fat genes that raise the risk of having an eating disorder 


Shocking figures show more than 1.2 million people in the UK are estimated to have an eating disorder, and hospital admissions for those severely affected have risen by more than a third in recent years. Meanwhile, Britain’s leading eating disorder charity, Beat, has reported an 80 per cent surge in calls to its helpline since […]

‘Jelly’ that could renew damaged knee joints


An injection of jelly could help treat worn-out joints. Scientists hope the jab, using jelly found in donated umbilical cords, will stimulate the growth of cushioning cartilage once injected into the knees of patients with osteoarthritis. Tests on animals suggest the jelly — called Wharton’s jelly — can potentially reverse damage to joints caused by […]

New ways to classify and study spinal cord neurons could inform therapies for illness or injury — ScienceDaily


Spinal cord nerve cells branching through the body resemble trees with limbs fanning out in every direction. But this image can also be used to tell the story of how these neurons, their jobs becoming more specialized over time, arose through developmental and evolutionary history. Salk researchers have, for the first time, traced the development […]

Further studies underway to determine extent of clinical benefits — ScienceDaily


A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis. A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of […]

Newly-discovered molecule provides dual protection against vascular inflammation — ScienceDaily


A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity. The study, published in the journal Nature Communications, revealed how one gene encoded two molecules […]

Genetic effects of Chernobyl radiation — ScienceDaily


In two landmark studies, researchers have used cutting-edge genomic tools to investigate the potential health effects of exposure to ionizing radiation, a known carcinogen, from the 1986 accident at the Chernobyl nuclear power plant in northern Ukraine. One study found no evidence that radiation exposure to parents resulted in new genetic changes being passed from […]

Scientists generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos — ScienceDaily


In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos. The use of animal embryos is also subject to restrictions rooted in ethical considerations. To overcome these limitations, scientists have been trying to recreate early embryos […]

Creativity and community: How modern humans overcame the Neanderthals


A new study is the first-ever to identify the genes for creativity in Homo sapiens that distinguish modern humans from chimpanzees and Neanderthals. The research identified 267 genes that are found only in modern humans and likely play an important role in the evolution of the behavioral characteristics that set apart Homo sapiens, including creativity, […]

Shift-work causes negative impacts on health, affects men and women differently — ScienceDaily


Shift-work and irregular work schedules can cause several health-related issues and affect our defence against infection, according to new research from the University of Waterloo. These health-related issues occur because the body’s natural clock, called the circadian clock, can be disrupted by inconsistent changes in the sleep-wake schedule and feeding patterns often caused by shift […]

‘Information theory’ recruited to help scientists find cancer genes — ScienceDaily


Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL). ALL is the most […]

Food allergies, changes to infant gut bacteria linked to method of childbirth, ethnicity — ScienceDaily


Researchers have found a causal link between caesarean section birth, low intestinal microbiota and peanut sensitivity in infants, and they report the effect is more pronounced in children of Asian descent than others, in a recently published paper in the journal of the American Gastroenterological Association. “It’s important to know what predicts or increases risk […]

The immune link between a leaky blood-brain barrier and schizophrenia — ScienceDaily


Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation — at least when all is functioning normally. That may not be the case in people with schizophrenia and other mental disorders, suggest new findings from a team led by researchers from […]

Repurposed drug works by building cells’ skeleton and transportation network — ScienceDaily


A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells, researchers concluded that the supplement likely protects proteins that build neurons’ cellular skeletons. The supplement betaine was first isolated from sugar beets and is often […]

A comprehensive roadmap of muscle decline with age in mice reveals possible new targets for treatments, including the molecule Klotho — ScienceDaily


Scientists have produced a comprehensive roadmap of muscle aging in mice that could be used to find treatments that prevent decline in muscle mobility and function, according to a report published today in eLife. The study reveals which molecules in the muscle are most significantly altered at different life stages, and shows that a molecule […]

Chickens and pigs with integrated genetic scissors — ScienceDaily


Researchers at the TUM have demonstrated a way to efficiently study molecular mechanisms of disease resistance or biomedical issues in farm animals. Researchers are now able to introduce specific gene mutations into a desired organ or even correct existing genes without creating new animal models for each target gene. This reduces the number of animals […]

Study based on data from 300,000 tests for COVID-19 — ScienceDaily


A new study at Tel Aviv University found that the British variant (termed: B.1.1.7) of Covid-19 is 45% more contagious than the original virus. The researchers relied on data from about 300,000 PCR tests for Covid-19 obtained from the COVID-19 testing lab, which was established in collaboration with the Electra Group. The new study was […]

New ‘time machine’ technique to measure cells — ScienceDaily


Using a new single-cell technique, WEHI researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered 30 new genes that program stem cells to make the dendritic cells that kick-start the immune response. By uncovering this process, the researchers hope they will be able to […]

New type of cell contributes to increased understanding of ALS — ScienceDaily


The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and […]

Metformin inhibits disease progression in non-diabetic chronic kidney disease (ND-CKD) — ScienceDaily


Researchers from Kumamoto University (Japan) have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin’s mechanism is different from existing therapeutics which only treat symptoms, […]

What does the study of domesticated birds tell us about the evolution of human language? Looking for keys of the human language evolution in bird singing — ScienceDaily


Language is one of the most notable abilities humans have. It allows us to express complex meanings and transmit knowledge from generation to generation. An important question in human biology is how this ability ended up being developed, and researchers from the universities of Barcelona, Cologne and Tokyo have treated this issue in a recent […]

Gene therapy shows promise in initial trial for patients with childhood blindness — ScienceDaily


A new gene therapy for one of the most common forms of congenital blindness was safe and improved patients’ vision, according to initial data from a clinical trial led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania. The therapy delivers working copies of GUCY2D to […]

CDC is watching for more cases of blood clots in people who got the J&J Covid vaccine


The Centers for Disease Control and Prevention (CDC) is reviewing additional reports of people who suffered severe side effects after receiving the Johnson & Johnson coronavirus vaccine. On Tuesday, the CDC and the U.S. Food and Drug Administration (FDA) suggested clinicians stop using the shot after nine reports of rare, but serious, blood clots out […]

Intellectual disability is rarely inherited — risk for younger siblings is low — ScienceDaily


The prevalence of intellectual disabilities, which means difficulties with learning and understanding new things, is roughly 1-2% in the population. People with a severe intellectual disability need help from others in daily activities throughout their lives. Such disabilities can be caused by genetic changes or external factors. According to estimates, roughly 2,500 genes underlie intellectual […]

Lateral flow Covid tests are being given to millions of schoolchildren with the WRONG instructions


Controversial lateral flow tests may have been sent out to millions of schoolchildren with the wrong instructions, it has emerged.  Many of the Chinese-made kits contained guidance saying they were to be used by people suffering symptoms of coronavirus — going against official UK guidance. The devices were also sent out with a notice that […]

Neural plasticity depends on this long noncoding RNA’s journey from nucleus to synapse — ScienceDaily


Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building connections among neurons, called synapses. How neurons do this — reaching out arm-like dendrites to communicate with other neurons — requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery. A […]

Virologists develop broadly protective coronavirus vaccines — ScienceDaily


A candidate vaccine that could provide protection against the COVID-19 virus and other coronaviruses has shown promising results in early animal testing. The candidate coronavirus vaccines, created by Virginia Tech’s University Distinguished Professor X.J. Meng and UVA Health’s Professor Steven L. Zeichner, prevented pigs from being becoming ill with a pig coronavirus, porcine epidemic diarrhea […]

Researchers find clues to sex differences in autism — ScienceDaily


It is well established that autism occurs much more frequently in boys than in girls, and that girls seem to have a greater resilience to developing the condition. It has been unclear, however, why that is. In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls […]

Scientists identify human genes that fight infection — ScienceDaily


Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body’s […]

New CRISPR technology offers unrivaled control of epigenetic inheritance — ScienceDaily


Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome — proteins and small molecules that latch onto DNA and control when and where genes are switched on or off. In a paper published April 9, 2021, in the journal Cell, […]

Medical student, 21, died a day after getting J&J vaccine


John Foley, 21 (pictured), a student at the University of Cincinnati in Ohio received the Johnson & Johnson coronavirus vaccine on Saturday and was discovered by his roommates on Sunday Officials are investigating the death of a University of Cincinnati student one day after receiving the Johnson & Johnson COVID-19 vaccine.  John Foley, 21, a […]

New discovery could lead to therapies for patients with Duchenne muscular dystrophy — ScienceDaily


A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, “A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression,” the study was […]

No10 hits back at lateral flow test fears after Matt Hancock adviser warning


Number 10 has today hit back at claims controversial rapid lateral flow coronavirus tests are dangerously unreliable.  The Prime Minister’s official spokesman said the kits, which give a result in under half an hour, ‘have been tested rigorously and we are confident that they are accurate’. It came after an adviser to Matt Hancock admitted as few […]

New method of artificially creating genetic switches for yeast — ScienceDaily


A group of researchers from Kobe University and Chiba University has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a model eukaryotic organism. The group consisted of Researcher TOMINAGA Masahiro*1, Associate Professor ISHII Jun*2 and Professor KONDO Akihiko*3 (of Kobe University’s Graduate School of Science, Technology and Innovation/Engineering Biology […]

A novel, quick, and easy system for genetic analysis of SARS-CoV-2 — ScienceDaily


SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have? Current methods for studying mutations in the SARS-CoV-2 genome are very complicated and time-consuming because coronaviruses have large genomes, but now a team from Osaka University […]

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos — ScienceDaily


The DNA molecule is not naked in the nucleus. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This 3D spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by […]

Get your head in the game — One gene’s role in cranial development — ScienceDaily


Researchers from Tokyo Medical and Dental University (TMDU) use genetic engineering in mice to further understand how cell fate is determined in the head Tokyo, Japan — Mammalian embryonic development is an extremely complex and precise process. Specific molecular events act as cues that tell cells in the embryo where to move and what type […]

New study links red meat consumption with heart disease


UK scientists have linked the consumption of any form of red meat – such as beef, lamb and pork – with a decline in heart function.  The researchers, who studied nearly 20,000 individuals, found that greater intake of red and processed meat was linked with a decline in three different measures of heart health.   Processed […]

Results bolster previous studies finding no growth, development differences with IVF — ScienceDaily


Compared to newborns conceived traditionally, newborns conceived through in vitro fertilization (IVF) are more likely to have certain chemical modifications to their DNA, according to a study by researchers at the National Institutes of Health. The changes involve DNA methylation — the binding of compounds known as methyl groups to DNA — which can alter […]

Penn Medicine discovery illuminates human sweat gland evolution — ScienceDaily


Humans have a uniquely high density of sweat glands embedded in their skin — 10 times the density of chimpanzees and macaques. Now, researchers at Penn Medicine have discovered how this distinctive, hyper-cooling trait evolved in the human genome. In a study published today in the Proceedings of the National Academy of Sciences, researchers showed […]

Coronavirus: One in 10 positive lateral flow tests in England turn out wrong when people retest


At least one in 10 positive results given by rapid lateral flow coronavirus tests were wrong in March, Public Health England has admitted. Since self-testing kits were put into mass use when schools in England reopened last month, 3,248 positive results have been found to be false by follow-up swab tests.  The controversial kits, which have […]

Exercise promotes healthy living and a healthy liver — ScienceDaily


Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting as much as a quarter of humanity. It is characterized by fat accumulation in liver cells and may progress to inflammation, cirrhosis and liver failure. Now, researchers at the University of Tsukuba reveal the positive effects, beyond the expected weight-loss benefit, of […]

Genetically modifying mosquitoes to express antimalarial genes and pass them on to their offspring is being tested as a new strategy to eliminate malaria — ScienceDaily


Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in eLife. The study is the latest in a series of steps toward using CRISPR-Cas9 gene-editing technology to make changes in mosquito genes […]

Amoeba biology reveals potential treatment target for lung disease — ScienceDaily


In a series of experiments that began with amoebas — single-celled organisms that extend podlike appendages to move around — Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment. “Physician-scientists […]

Aging signatures across diverse tissue cells in mice — ScienceDaily


Researchers have identified molecular signatures of the aging process in mice, publishing their results today in the open-access eLife journal. Their analyses provide one of the most comprehensive characterisations of the molecular signatures of aging across diverse types of cells from different tissues in a mammal, and will aid future studies on aging and related […]

165 new cancer genes identified with the help of machine learning — ScienceDaily


A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with “Artificial Intelligence” and identified numerous cancer genes. This opens up new perspectives for targeted cancer therapy in personalized medicine and for the development […]

Spit samples uncover genetic risk factors for pediatric obsessive-compulsive disorder — ScienceDaily


Researchers at the University of Calgary and The Hospital for Sick Children (SickKids), in Toronto, have discovered genetic risk factors for OCD that could help pave the way for earlier diagnosis and improved treatment for children and youth. “Our group made the first finding of a genome-wide significant risk gene relevant to childhood OCD,” says […]

Using genetics, researchers identify potential drugs for early treatment of COVID-19 — ScienceDaily


A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine in March 2021. Based on their analyses, the researchers are calling for prioritizing clinical trials of drugs targeting the proteins IFNAR2 […]

Researchers discover new way to starve brain tumors — ScienceDaily


Scientists from Queen Mary University of London, funded by the charity Brain Tumour Research, have found a new way to starve cancerous brain tumour cells of energy in order to prevent further growth. The pre-clinical research in human tissue samples, human cell lines and mice could lead to changes in the way that some children […]

Inheriting acquired traits requires trailblazer modifications to unfertilized eggs — ScienceDaily


An epigenetic study at the RIKEN Center for Integrative Medical Sciences shows that in mouse egg cells, modifications to histone H2A at lysine 119 lay the groundwork for inherited DNA functional modifications from the mother. In books and the movies, a group of people on a special mission always sends out a scout to do […]

Scientists say human embryos could be grown in a test tube for FIVE WEEKS after mice develop in jars


Human embryos could be the next test subjects of a groundbreaking study that kept mouse embryos alive outside of the womb that developed a heart, stomach, head and limbs in six days. A team of Israeli scientists grew filled small jars with nutrients inside that were placed on rotating roller and pumped each with a pressurized […]

Doctors explain the reactions after receiving Pfizer, Moderna or Johnson & Johnson shots


Millions of Americans are currently receiving coronavirus vaccinations as the U.S. works to restore some sense of normalcy from the pandemic According to the Centers for Disease Control and Prevention (CDC), 30 percent of the U.S. population has received at least one dose and 16.9 percent are fully immunized, either from Pfizer-BioNTech, Moderna or Johnson […]

DR MICHAEL MOSLEY: Stand on one leg to brush your teeth!


My son Daniel revels in it, but for me, that daily shower — or rather, the 40-second blast of pure cold water at the end — is something I rather dread. Of course, the discomfort is momentary, and afterwards I feel alert and ready for the day.  This is one of ten really simple things, […]

Georgia clinic is the FOURTH to halt J&J vaccinations within three days


Millions of Americans are currently receiving coronavirus vaccinations as the U.S. works to restore some sense of normalcy from the pandemic. According to the Centers for Disease Control and Prevention (CDC), 33 percent of the US population has received at least one dose and 19.4 percent are fully immunized, either from Pfizer-BioNTech, Moderna or Johnson […]

Blocking a protein could help overcome cancer resistance to PARP inhibitors — ScienceDaily


Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumour sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers. Some cancers, including certain breast, ovarian and prostate tumours, are caused by a […]

Scientists discover ‘jumping’ genes that can protect against blood cancers — ScienceDaily


New research has uncovered a surprising role for so-called “jumping” genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children’s Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against […]

Health minister defends use of controversial lateral flow tests in No10’s new twice-a-week plan


Experts today lined up to attack Number 10 for a bold new plan to screen the entire nation for coronavirus twice a week using lateral flow tests. Critics of the controversial kits – which offer results in half an hour – called the scheme ‘beyond reckless’, a ‘public health disaster’ and a ‘scandalous’ waste of […]

Metabolic changes in fat tissue in obesity associated with adverse health effects — ScienceDaily


Researchers at the Obesity Research Unit of the University of Helsinki have found that obesity clearly reduces mitochondrial gene expression in fat tissue, or adipose tissue. Mitochondria are important cellular powerplants which process all of our energy intake. If the pathways associated with breaking down nutrients are lazy, the changes can often have health-related consequences. […]

A clinical study finds a biomarker for the action of glucocorticoids that could be used for developing tests to help clinicians tailor treatments — ScienceDaily


Researchers have uncovered pathways involved in the body’s response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife. A more reliable indicator of an individual’s response to glucocorticoid drugs could be used to develop a […]

DNA markers in cells of MDD sufferers appear 2 years older than in healthy controls, researchers say — ScienceDaily


Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others. Methylation is a process by […]

Key brain molecule may play role in many brain disorders — ScienceDaily


A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions. The results, published in Cell Reports, illuminate an important process in the […]

Itching sensation originates in the skin cells themselves, after signaling from an excess of lipid — ScienceDaily


A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation. The finding, which appears April 2 in Gastroenterology, indicates that the keratinocyte cells […]

Why 2020 was the year of marvellous medicine


A year ago, the world was in the grip of a deadly and, seemingly, unstoppable virus and the UK went into its first lockdown.  Since then, vaccines and life-saving drugs to counter Covid have been the focus of international attention.  But the past year has also seen major developments in treatments for cancer, diabetes, multiple […]

Boris confirms shops CAN reopen on Monday – but is lockdown roadmap in doubt?


The government was today accused of deploying ‘Project Fear’ tactics and doomsday worst case scenarios to justify prolonging coronavirus restrictions – despite the government’s own predictions showing that any third wave of coronavirus this summer is likely to be manageable. A third wave of Covid when restrictions are lifted in June is likely to be […]

Ancient genomes shed new light on the earliest Europeans and their relationships with Neanderthals — ScienceDaily


An international research team has sequenced the genomes of the oldest securely dated modern humans in Europe who lived around 45,000 years ago in Bacho Kiro Cave, Bulgaria. By comparing their genomes to the genomes of people who lived later in Europe and in Asia the researchers from the Max Planck Institute for Evolutionary Anthropology […]

Social isolation results in changes of behavior and activity of immune and stress genes — ScienceDaily


Ants react to social isolation in a similar way as do humans and other social mammals. A study by an Israeli-German research team has revealed alterations to the social and hygienic behavior of ants that had been isolated from their group. The research team was particularly surprised by the fact that immune and stress genes […]

How to tame a restless genome — ScienceDaily


Short pieces of DNA — jumping genes — can bounce from one place to another in our genomes. When too many DNA fragments move around, cancer, infertility, and other problems can arise. Cold Spring Harbor Laboratory (CSHL) Professor & HHMI Investigator Leemor Joshua-Tor and a research investigator in her lab, Jonathan Ipsaro, study how cells […]

Findings lead to the development of therapeutic strategies to overcome it — ScienceDaily


A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. In a new article published […]

Complete chromosome 8 sequence reveals novel genes and disease risks — ScienceDaily


The full assembly of human chromosome 8 is reported this week in Nature. While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally. […]