Engineering T cells to attack cancer broadly — ScienceDaily


[ad_1] Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it’s possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues. This research will be published in tomorrow’s print edition of Cancer Research. The paper builds on decades of research by […]

Stress slows the immune response in sick mice — ScienceDaily


[ad_1] The neurotransmitter noradrenaline, which plays a key role in the fight-or-flight stress response, impairs immune responses by inhibiting the movements of various white blood cells in different tissues, researchers report April 28th in the journal Immunity. The fast and transient effect occurred in mice with infections and cancer, but for now, it’s unclear whether […]

Wildfire smoke linked to skin disease — ScienceDaily


[ad_1] Wildfire smoke can trigger a host of respiratory and cardiovascular symptoms, ranging from runny nose and cough to a potentially life-threatening heart attack or stroke. A new study suggests that the dangers posed by wildfire smoke may also extend to the largest organ in the human body, and our first line of defense against […]

Health campaign style is as important as content, research suggests — ScienceDaily


[ad_1] Most young women already know that tanning is dangerous and sunbathe anyway, so a campaign informing them of the risk should take into account their potential resistance to the message, according to a new study. Word choice and targeting a specific audience are part of messaging strategy, but there is also psychology at play, […]

Study reveals crucial details on skin-related side effects of cancer immune therapies — ScienceDaily


[ad_1] Immune checkpoint inhibitors, which boost the immune system’s response against tumor cells, have transformed treatment for many advanced cancers, but short-term clinical trials and small observational studies have linked the medications with various side effects, most commonly involving the skin. A more comprehensive, population-level analysis now provides a thorough look at the extent of […]

Results will help guide care for many patients with advanced cancer — ScienceDaily


[ad_1] Many patients with cancer receive immune checkpoint inhibitors that strengthen their immune response against tumor cells. While the medications can be life-saving, they can also cause potentially life-threatening side effects in internal organs. This double-edged sword makes it challenging for clinicians to decide who should be considered candidates for treatment. A new analysis led […]

Novel immunotherapy approach to fight melanoma — ScienceDaily


[ad_1] In a new study led by Yale Cancer Center, researchers have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response to help treat melanoma. The study was presented today at the American Association of Cancer Research (AACR) virtual annual meeting. “Most approaches rely on direct injection into […]

NHS patients to be offered cancer treatment at home


[ad_1] Thousands of NHS patients could be given cutting-edge cancer treatments in the comfort of their own living rooms this year in a drive to spare them from repeat hospital visits. Specialist nurses from top cancer centre The Christie NHS Foundation Trust in Manchester are already offering at-home chemotherapy and immunotherapy to 250 patients a day, […]

I got deadly skin cancer in my garden… in Surrey


[ad_1] The chances of taking a foreign holiday this summer still look remote for most of us. Not that this bothers mother-of-three Jackie Palmer, who has never felt the urge to go abroad The chances of taking a foreign holiday this summer still look remote for most of us.  Not that this bothers mother-of-three Jackie […]

An amyloid link between Parkinson’s disease and melanoma — ScienceDaily


[ad_1] On the surface, Parkinson’s disease — a neurodegenerative disorder — and melanoma — a type of skin cancer — do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson’s disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular […]

A drug that can stop tumors from growing — ScienceDaily


[ad_1] Cancer doctors may soon have a new tool for treating melanoma and other types of cancer, thanks to work being done by researchers at the University of Colorado Cancer Center. In a paper published in the journal PNAS last month, CU Cancer Center members Mayumi Fujita, MD, PhD, Angelo D’Alessandro, PhD, Morkos Henen, PhD, […]

Findings lead to the development of therapeutic strategies to overcome it — ScienceDaily


[ad_1] A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma. However, some patients do not show beneficial clinical responses to these novel and very promising immunotherapies. In a new article […]

Sëmundjet dhe kushtet e zakonshme të lëkurës


[ad_1] Ka qindra gjendje të lëkurës që prekin njerëzit. Kushtet më të zakonshme të lëkurës mund të kenë disa simptoma që janë të ngjashme, andaj është e rëndësishme të kuptoni ndryshimet midis tyre, transmeton Gazeta Sinjali. Njerëzit duhet të punojnë ngushtë me një dermatolog për të diagnostikuar dhe trajtuar çdo gjendje të lëkurës për të […]

Melanoma: Kush rrezikohet më shumë nga shfaqja e saj?


[ad_1] Rreziku për zhvillimin e melanomës përfshin njerëzit që kanë shumë nishane shumë të errëta dhe të çrregullta. Sidoqoftë, melanoma mund të zhvillohet edhe nga një rritje e re në lëkurë. Melanoma shkaktohet nga një ndryshim në qelizat që prodhojnë melaninë (melanocitet) që i japin ngjyrën e lëkurës. Në rrethana normale, qelizat e lëkurës zhvillohen […]

Cila ngjyrë e urinës është një shenjë e sëmundjeve të rrezikshme


[ad_1] Shumica prej nesh s’ ju pëlqen të flasin për gjëra të tilla si urina, por realiteti është që këto sekrecione janë të rëndësishme për shëndetin tonë. Me siguri keni pyetur veten të paktën një herë se pse urina juaj është e errët dhe çfarë mund të shkaktojë? Ka disa gjëra që janë të dukshme […]

6 Arsye Pse duhet Ti Kontrolloni Nishanet Edhe Gjatë Stinës Së Dimirit


[ad_1] Dëmtimi i nishaneve ndodh në mënyrë graduale dhe s’ ndodh gjithmonë menjëherë pas ekspozimit në diell. Kështu që gjatë dimrit ndryshimet që nishanet mund të pësojnë, rrezikojnë të kalojnë pa u vërejtur, përse të gjithë jemi të mbështjellë nga shtresa të shumta veshjesh dhe harrojmë t’i kontrollojmë. A duhet të vendosni krem mbrojtës gjatë […]

Cancer shifts to chronic disease, so living well matters


[ad_1] Professor Emily Banks. Credit: Australian National University Improved survival means cancer is increasingly a chronic disease, and a lot of people are living well with it, new research from The Australian National University (ANU) shows. The study, the largest of its kind in the world, has looked at data from more than 22,000 people […]

Big data powers design of ‘smart’ cell therapies for cancer


[ad_1] Credit: CC0 Public Domain Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with “smart” cell therapies—living medicines that remain inert unless triggered by combinations […]

Study identifies patients with lung cancer most likely to respond to immunotherapy


[ad_1] Lung CA seen on CXR. Credit: James Heilman, MD/Wikipedia Scientists are beginning to unravel one of the biggest challenges with immunotherapy: why some people with cancer respond to the treatment, while others may not respond at all. In a new study, researchers at the UCLA Jonsson Comprehensive Cancer Center found patients with a particular […]

A better test for the tumor-targeting of CAR-T therapies


[ad_1] Credit: CC0 Public Domain Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system’s T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment. Published in […]

Novel adoptive cell transfer method shortens timeline for T-cell manufacture


[ad_1] A faster approach for T-cell therapy against cancer. Knochelmann and colleagues show a subset of CD4 T-cells, Th17 cells, can effectively kill tumor cells when they are grown in cell culture for only four days. Th17 cells grown for shorter or longer periods of time cannot successfully eradicate the tumor. Additionally, the cytokine IL-6 […]

She Had a Headache for Months. Then She Could Barely See.


[ad_1] The 61-year-old woman put on her reading glasses to try to decipher the tiny black squiggles on the back of the package of instant pudding. Was it two cups of milk? Or three? The glasses didn’t seem to help. The fuzzy, faded marks refused to become letters. The right side of her head throbbed […]

Map the fundamentals of how cells go awry


[ad_1] Credit: CC0 Public Domain Someday, scientists may be able to prevent cancer by controlling two proteins that operate deep inside the quagmire of epigenetic cell fate transitions, a new paper suggests. Published by Nature Communications, the article describes a dynamic push and pull between the proteins ANP32E and H2AZ. Their relationship is significant because […]

Aggressive melanoma cells at edge of tumours are key to cancer spread


[ad_1] Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0 Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body. The findings from the study may help […]

How melanoma deceives the immune system, increasing resistance to immunotherapy


[ad_1] Credit: CC0 Public Domain The sophisticated human immune system has evolved to become an effective protection system against a great number of diseases, including cancer. The immune system recognizes and destroys cancer cells using a monitoring process called immunological surveillance. However, like Dr. Jekyll and his alter ego Mr. Hyde, the immune system sometimes […]

Çfarë vret helmi i bletës?


[ad_1] Shkencëtarët australianë thonë se helmi nga bletët është zbuluar se shkatërron qelizat agresive të kancerit të gjirit në një mjedis laboratorik. Helmi – dhe një përbërje në të e quajtur ‘melittin’ – u përdorën kundër dy llojeve të kancerit të cilat janë të vështira për t’u trajtuar: tre-negativ dhe i pasuruar me HER2. Zbulimi […]

Genomic study of 6000 NCI-MATCH cancer patients leads to new clinical trial benchmarks


[ad_1] NCI-MATCH is a precision medicine cancer trial is that seeks to determine whether matching certain drugs or drug combinations in adults whose tumors have specific gene abnormalities will effectively treat their cancer, regardless of their cancer type. Such discoveries could be eligible to move on to larger, more definitive trials. The trial is led […]

Nishanet në Trup – Çfarë Paralajmërojnë për Shëndetin


[ad_1] Nishanet ose njollat e zeza që shfaqen në lëkurë kanë përmasa dhe forma të ndryshme. Ato shfaqen në pjesë të ndryshme të fytyrës, shpatullave, krahëve dhe pjesës së sipërme të trupit. Disa prej këtyre njollave janë të vogla e të sheshta ndërsa disa të tjera ngjajnë më të errëta në ngjyrë dhe të dala […]

Gut microbiome may influence how cancer patients respond to oral therapies, study suggests


[ad_1] Brendan Daisley, a PhD candidate at Western University’s Schulich School of Medicine & Dentistry who is conducting research at Lawson Health Research Institute Credit: Lawson Health Research Institute A new study from Lawson Health Research Institute and Western University illustrates how the gut microbiome interacts with an oral medication in prostate cancer patients, suggesting […]