New research outlines a critical driver in an immune cell’s defense against melanoma — ScienceDaily

Today in Nature Communications, researchers at Huntsman Cancer Institute at the University of Utah report critical new insights into how cells mount an attack against melanoma tumors. Melanoma is an aggressive type of skin cancer that can arise from excess exposure to sun, frequent sunburns, genetics, and other environmental factors. Melanoma, like all cancers, begins […]

Lighting up biology from within — ScienceDaily

A biochemical reaction between an enzyme called luciferase and oxygen causes fireflies to glow and is considered one of the most well-known examples of bioluminescence in nature. Now, an international team of researchers led by Elena Goun at the University of Missouri is working to harness the power of bioluminescence in a low-cost, noninvasive portable […]

How to predict severe influenza in hospitalized patients — ScienceDaily

Published today in Nature Communications, the team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), Alfred Health and Monash University sought to understand which patients would recover quickly from influenza and which would become severely ill. The four-year project took samples from patients hospitalised with influenza at up to five time points […]

Proof-of-principle research shows that genes can be accurately edited in cells throughout the body — ScienceDaily

Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques. Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier’s laboratory demonstrates that new DNA repair […]

A new approach for treating obesity — ScienceDaily

A receptor that helps conserve energy when food is scarce may be the key to a safer approach to treating diet-induced obesity, research led by the Garvan Institute of Medical Research has revealed. In a study using experimental models and fat tissue biopsies from obese individuals, the team revealed that blocking a specific receptor of […]

How one of the oldest natural insecticides keeps mosquitoes away — ScienceDaily

With mosquito season upon us, people are stocking up on repellents to prevent itchy bites. Bug repellents are important because they don’t just protect against the buzzing, blood-sucking little pests — they also safeguard against the diseases they carry, which kill some 700,000 people worldwide each year. Surprisingly, despite widespread use, no one understood exactly […]

Researchers have determined the virus’ protein-coding gene set and analyzed new mutations’ likelihood of helping the virus adapt — ScienceDaily

In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2. While many of its genes were already known at that point, the full complement of protein-coding genes was unresolved. Now, after performing an extensive comparative genomics study, MIT […]

How proteins control information processing in the brain — ScienceDaily

A complicated interaction between different proteins is needed for information to pass from one nerve cell to the next. Researchers at the Martin Luther University Halle-Wittenberg (MLU) have now managed to study this process in the synaptic vesicles, which play an important role in this process. The study appeared in the journal Nature Communications. Several […]

New finding suggests cognitive problems caused by repeat mild head hits could be treated — ScienceDaily

A neurologic pathway by which non-damaging but high frequency brain impact blunts normal brain function and causes long-term problems with learning and memory has been identified. The finding suggests that tailored drug therapy can be designed and developed to reactivate and normalize cognitive function, say neuroscientists at Georgetown University Medical Center. The investigators, working with […]

Research results challenge a decades-old mechanism of how we hear sounds — ScienceDaily

Researchers at Linköping University, Sweden, have made several discoveries on the functioning mechanisms of the inner hair cells of the ear, which convert sounds into nerve signals that are processed in the brain. The results, presented in the scientific journal Nature Communications, challenge the current picture of the anatomical organisation and workings of the hearing […]

DR MICHAEL MOSLEY: How fasting could help cut your blood pressure

Regular readers of this column might wonder if I am ever so slightly obsessed with the microbiome, the billions of tiny creatures that live in our guts — and you’d be right. I’m fascinated by these extraordinary microbes, and the ongoing battle between the ‘good’ and the bad’ ones, that influences so much about us, […]

Mouse study provides atlas to pinpoint neurons involved in neurodegenerative diseases — ScienceDaily

In a mouse study, National Institutes of Health researchers have identified and mapped a diverse spectrum of motor neurons along the spinal cord. These neurons, which send and receive messages throughout the body, include a subset that is susceptible to neurodegenerative diseases. Created with a genetic sequencing technique, the atlas reveals 21 subtypes of neurons […]

New genetic target for blood cancer treatment — ScienceDaily

Targeting a pathway that is essential for the survival of certain types of acute myeloid leukaemia could provide a new therapy avenue for patients, the latest research has found. Researchers from the Wellcome Sanger Institute found that a specific genetic mutation, which is linked with poor prognosis in blood cancer, is involved in the development […]

How does the brain flexibly process complex information? — ScienceDaily

Human decision-making depends on the flexible processing of complex information, but how the brain may adapt processing to momentary task demands has remained unclear. In a new article published in the journal Nature Communications, researchers from the Max Planck Institute for Human Development have now outlined several crucial neural processes revealing that our brain networks […]

Ky suplement mund t’ju ndihmojë të jetoni 13 për qind më gjatë

Acidet yndyrore Omega-3, që shpesh gjenden në suplementet e vajit të peshkut dhe prodhimet e tjera të detit, kanë marrë prej kohësh reputacionin se janë të dobishme për shëndetin fizik dhe mendor. Tani, një studim i ri tregon se sa thelbësore janë ato për mirëqenien e përgjithshme – përfshirë edhe jetëgjatësinë. Kërkimi i botuar së fundmi […]

Ship traffic dropped during first months of COVID pandemic — ScienceDaily

Ship movements on the world’s oceans dropped in the first half of 2020 as Covid-19 restrictions came into force, a new study shows. Researchers used a satellite vessel-tracking system to compare ship and boat traffic in January to June 2020 with the same period in 2019. The study, led by the University of Exeter (UK) […]

New method preserves viable fruit fly embryos in liquid nitrogen — ScienceDaily

Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster) — which is crucial to genetics research and critical to scientific breakthroughs benefiting human health — has not been available. “To keep alive the ever-increasing […]

Newly-discovered molecule provides dual protection against vascular inflammation — ScienceDaily

A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity. The study, published in the journal Nature Communications, revealed how one gene encoded two molecules […]

Removing ‘garbage’ from brain cells improves memory in mice — ScienceDaily

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer’s disease in mice. The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting and recycling them. The study was published online today in the journal Cell. “Discoveries in mice don’t […]

Freeze! Executioner protein caught in the act — ScienceDaily

A new molecular ‘freeze frame’ technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells. Small proteins called ‘monobodies’ were used to freeze MLKL at different stages as it moved from a dormant to an activated state, a key process that enables an inflammatory form of cell death called […]

Drug development platform could provide flexible, rapid and targeted antimicrobials — ScienceDaily

When disease outbreaks happen, response time in developing and distributing treatments is crucial to saving lives. Unfortunately, developing custom drugs as countermeasures is often a slow and difficult process. But researchers at the University of Colorado Boulder have created a platform that can develop effective and highly specific peptide nucleic acid therapies for use against […]

Pandemic eviction bans found to protect entire communities from COVID-19 spread — ScienceDaily

A new study led by researchers at Johns Hopkins and the University of Pennsylvania uses computer modeling to suggest that eviction bans authorized during the COVID-19 pandemic reduced the infection rate and not only protected those who would have lost their housing but also entire communities from the spread of infections. With widespread job loss […]

MK-4482 shows potential to prevent and treat SARS-CoV-2 infection — ScienceDaily

The experimental antiviral drug MK-4482 significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection, according to a new study from National Institutes of Health scientists. SARS-CoV-2 is the virus that causes COVID-19. MK-4482, delivered orally, is now in human clinical trials. Remdesivir, an antiviral drug already approved […]

New method of artificially creating genetic switches for yeast — ScienceDaily

A group of researchers from Kobe University and Chiba University has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a model eukaryotic organism. The group consisted of Researcher TOMINAGA Masahiro*1, Associate Professor ISHII Jun*2 and Professor KONDO Akihiko*3 (of Kobe University’s Graduate School of Science, Technology and Innovation/Engineering Biology […]

Lipid research may help solve COVID-19 vaccine challenges — ScienceDaily

New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain COVID-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online April 13 in Nature Communications, the researchers demonstrate a new, inexpensive […]

Study links structural brain changes to behavioral problems in children who snore — ScienceDaily

A large study of children has uncovered evidence that behavioral problems in children who snore may be associated with changes in the structure of their brain’s frontal lobe. The findings support early evaluation of children with habitual snoring (snoring three or more nights a week). The research, published in Nature Communications, was supported by the […]

Researchers identify a novel way of how a common bacterium can learn to live within the human stomach — ScienceDaily

Humans are exposed to many types of bacteria daily, the majority of which are harmless. However, some bacteria are pathogenic, which means they can cause disease. An extremely common pathogenic bacterial infection is Helicobacter pylori (H. pylori) in the stomach, where it can lead to chronic inflammation (gastritis), ulcers, and even cancer. A group of […]

Volcanic pollution return linked to jump in respiratory disease cases — ScienceDaily

Respiratory disease increased markedly following one of Iceland’s largest volcanic eruptions, a new study has found. And the findings could have significant implications for actions taken to protect the health of the 800 million people globally living near active volcanoes. Indeed, only last month (March), lava burst through a crack in Iceland’s Mount Fagradalsfjall in […]

Researchers discover new way to starve brain tumors — ScienceDaily

Scientists from Queen Mary University of London, funded by the charity Brain Tumour Research, have found a new way to starve cancerous brain tumour cells of energy in order to prevent further growth. The pre-clinical research in human tissue samples, human cell lines and mice could lead to changes in the way that some children […]

The tuberculosis pathogen releases its toxin by a novel protein transport system — ScienceDaily

Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the founding member of a novel class of previously unrecognized toxins present in more than 600 bacterial and fungal species, as determined by protein sequence similarity. The toxin is […]

Scientists reveal elusive inner workings of antioxidant enzyme with therapeutic potential — ScienceDaily

Mitochondria, known as the powerhouses within human cells, generate the energy needed for cell survival. However, as a byproduct of this process, mitochondria also produce reactive oxygen species (ROS). At high enough concentrations, ROS cause oxidative damage and can even kill cells. An overabundance of ROS has been connected to various health issues, including cancers, […]

Studimi/ Fëmijët prodhojnë më shumë antitrupa ndaj Covid-19

Fëmijët deri në 10 vjeç prodhojnë më shumë antitrupa në përgjigje të infeksionit të koronavirusit sesa adoleshentët dhe të rriturit, tregoi një studim të hënën. Autorët e punimit, i cili u shfaq në JAMA Network Open, thanë se gjetja ndihmoi të ndriçojë pse fëmijët janë më pak të ndjeshëm ndaj Covid-19 të rëndë se të […]

Why 2020 was the year of marvellous medicine

A year ago, the world was in the grip of a deadly and, seemingly, unstoppable virus and the UK went into its first lockdown.  Since then, vaccines and life-saving drugs to counter Covid have been the focus of international attention.  But the past year has also seen major developments in treatments for cancer, diabetes, multiple […]

Përdorimi i antibiotikëve në ditët e para të jetës pengon rritjen e foshnjave

Terapia me antibiotikë te të porsalindurit, veçanërisht në ditët e para të jetës, mund të ketë pasoja të rënda afatgjata. ndërsa është e domosdoshme në disa raste, mund të ketë një efekt negativ në rritje. Ky është rezultati i një studimi të botuar në revistën Nature Communications, i cili tregon se si përdorimi i antibiotikëve mund […]

Shkencëtarët më afër të kuptuarit të sëmundjes së Parkinsonit

Një informacion i ri i zbuluar nga studiuesit e Universitetit të Kembrixhit mund të shënojë një hap jetik në të kuptuarit e sëmundjes së Parkinsonit, një çrregullim neurologjik dobësues, sipas hulumtimit të ri. Një letër e botuar sot në revistën “Nature Communications” përshkron atë që universiteti thotë se është “prova bindëse e re” në lidhje […]

Zvogëloni rrezikun e kancerit të gjirit me këtë ndryshim të vogël në ushqyerje

Kanceri i gjirit është kanceri i dytë më i zakonshëm në Shtetet e Bashkuara, duke prekur një në tetë gra. Duke pasur parasysh përhapjen e tij, shumë prej nesh po kërkojnë hapa të lehtë parandalues ​​për të ulur rrezikun tonë të kancerit, si ngrënia e vakteve të shëndetshme dhe të ekuilibruar. Por ndërsa dieta juaj […]

Pse disa persona janë impulsiv?

Kontrolli i emocioneve, mund të jetë shumë i vvështirë për disa persona. Një hulumtim i bërë së fundmi, ka analizuar arsyen pse disa persona bëhen impulsiv? Autorët e një hulumtimi të publikuar në Nature Communications, kanë definuar impulsin si ‘përgjigje e shpejtë pa i menduar veprimet e tjetrit”. Sipas tyre, të jesh impulsiv s’ është […]

Forschungsgruppe entdeckt für Biodiversität verantwortliches Gen

Die Arbeitsgruppe von Christiane Nüsslein-Volhard am Max-Planck-Institut für Entwicklungsbiologie in Tübingen hat ein Gen identifiziert, das für die unterschiedlichen Muster von nahverwandten Arten des Zebrabärblings Danio rerio mitverantwortlich ist. Das Gen, Obelix, codiert für einen Kaliumkanal; diese Klasse von Proteinen steuert zahlreiche zelluläre Prozesse, die in einigen menschlichen Krankheiten gestört sind. Ihre Ergebnisse haben sie […]

Drinking blocks a chemical that promotes attention

Martin Paukert, M.D., of the Joe R. and Teresa Lozano Long School of Medicine at The University of Texas Health Science Center at San Antonio, is studying astroglia cells and how they interact with neurons in the brain. Credit: UT Health San Antonio In a new paper, researchers from The University of Texas Health Science […]

New lab-on-a-chip infection test could provide cheaper, faster portable diagnostics

Credit: Imperial College London The chip, developed at Imperial College London and known as TriSilix, is a ‘micro laboratory’ which performs a miniature version of the polymerase chain reaction (PCR) on the spot. PCR is the gold-standard test for detecting viruses and bacteria in biological samples such as bodily fluids, faeces, or environmental samples. Although […]

Warning signs over effectiveness of HIV ‘wonder drug’ in sub-Saharan Africa

Scanning electromicrograph of an HIV-infected T cell. Credit: NIAID Dolutegravir, the current first-line treatment for HIV, may not be as effective as hoped in sub-Saharan Africa, suggests new research published on World AIDS Day. The study finds that this so-called ‘wonder drug’ may be less effective in patients resistant to older drugs. As HIV copies […]

Bakterien mit fluoreszierenden Nanosensoren detektieren

Eine neue Methode zur Detektion von Bakterien und Infektionen haben ForscherInnen aus Bochum, Göttingen, Duisburg und Köln entwickelt. Sie nutzen fluoreszierende Nanosensoren, um Krankheitserreger schneller und einfacher aufzuspüren als das mit etablierten Verfahren möglich ist. Um Bakterien mit herkömmlichen Methoden zu detektieren, müssen Gewebeproben entnommen und analysiert werden. Die Gruppe um Prof. Sebastian Kruß möchte […]

Researcher uses fruit for less toxic drug delivery

UofL researchers have found a less toxic way to deliver medicines by using the natural lipids in plants, particularly grapefruit and ginger. The resulting intellectual property portfolio consisting of 12 patent families, invented by Huang-Ge Zhang, Ph.D., has been licensed to Boston-based Senda BioSciences, a Flagship Pioneering company. UofL’s technology is part of Senda’s efforts […]

Und der Haifisch, der hat Zähne: Besonderheit im Zahnschmelz von Haifischzähnen entdeckt

Haifischzähne müssen während ihrer kurzen Verweildauer auf den Punkt funktionieren: Der Port-Jackson-Stierkopfhai ernährt sich von harten Beutetieren wie Seeigeln und Muscheln. Seine Zähne müssen kontinuierlich hoher mechanischer Beanspruchung standhalten. Dies gewährleistet die besondere Struktur des Zahnschmelzes: „Die Besonderheit besteht darin, dass die innere Zahnschmelzschicht für Stabilität sorgt, während die äußere sukzessive absplittert. Dadurch behält der […]

SARS-CoV-2 mutations do not appear to increase transmissibility

A colorized scanning electron micrograph of the SARS-CoV-2 virus. Credit: NIAID None of the mutations currently documented in the SARS-CoV-2 virus appear to increase its transmissibility in humans, according to a study led by UCL researchers. The analysis of virus genomes from over 46,000 people with COVID-19 from 99 countries is published today in Nature […]

Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine

Antibodies from engineered B cells approach an HIV particle (shown in blue) to disable it. In a new study, scientists found that gene-edited B cells can generate durable protective antibody responses against HIV when activated with a vaccine. Credit: Illustration courtesy of the Voss laboratory at Scripps Research. Unlike so many other deadly viruses, HIV […]

Ovarian cancer cells cooperate to metastasize

Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen at the top of image. Credit: Nephron /Wikipedia. CC BY-SA 3.0 Any given tumor is […]

3-D bioprinted heart provides new tool for surgeons

Credit: Unsplash/CC0 Public Domain Professor of Biomedical Engineering Adam Feinberg and his team have created the first full-size 3-D bioprinted human heart model using their Freeform Reversible Embedding of Suspended Hydrogels (FRESH) technique. Showcased in a recent video by American Chemical Society and created from MRI data using a specially built 3-D printer, the model […]

New study could help predict which individuals are more susceptible to cancer-causing agents

Credit: Pixabay/CC0 Public Domain New insights into the mechanisms behind how cancer-causing agents in the environment activate genetic recombination in DNA could help to explain some of the effects of exposure as well as predicting which individuals may be more susceptible to developing the disease, a new UK study has suggested. Everyone is exposed to […]

HIV: Neuer Mechanismus entdeckt – Biermann Medizin

Der Kampf gegen HIV ist auch nach jahrelanger Forschung nicht gewonnen. Ein wichtiger Schritt zur Entwicklung besserer Therapien ist ein gutes Verständnis davon, wie sich das Virus auf molekularer Ebene im Körper vermehrt. Ein Team um Kathrin Breuker hat nun einen Mechanismus entschlüsselt, der für die Vermehrung des Virus zentral ist und ein neues Angriffsziel […]

Smell and taste changes provide early indication of COVID-19 community spread

Researchers find that self-reports of smell and taste changes provide earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators. Credit: Engin Akyurt, Unsplash Self-reports of smell and taste changes provide earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators, according to an international team of researchers. The […]

Technique to regenerate optic nerve offers hope for future glaucoma treatment

Credit: Unsplash/CC0 Public Domain Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. Axons—nerve fibres—in the adult central nervous system (CNS) do not normally regenerate after injury and disease, meaning […]

Physik-Modell: Ausbreitungen von Infektionskrankheiten verstehen

Physiker der Westfälischen Wilhelms-Universität Münster haben in Modell-Simulationen nachgewiesen, dass die COVID-19-Infektionszahlen durch „Social Distancing“ deutlich sinken. Die Wissenschaftler kombinierten dazu die „dynamische Dichtefunktionaltheorie“ zur Beschreibung von wechselwirkenden Teilchen und das „SIR-Modell“, eine Theorie zur Beschreibung der Ausbreitung von Infektionskrankheiten. Infolge des weltweiten Ausbruchs der Krankheit COVID-19, verursacht durch das neue Coronavirus SARS-CoV-2, arbeiten Wissenschaftlerinnen […]

Shtatë mënyra drithëruese se si stresi mund të ndryshojë fizikisht trurin tuaj

Në doza të vogla, stresi mund t’ju motivojë të përfundoni një detyrë të caktuar apo të arrini një qëllim, por kur stresi bëhet kronik, ju mund të filloni të përjetoni të gjitha llojet e efekteve anësore dhe simptomave, si rezultat. Stresi mund të shkaktojë edhe ndryshime fizike në trurin tuaj: 1 – Mund të ndikojë […]

Studim- Harroni shpesh atë se çfarë doni të thoni? Ja pse ju ndodh

Secilit nga ne i ndodh të harrojë atë se çfarë donit të thonit kur dikush ju ka ndërprerë! Studimi ka shpjeguar origjinën e këtij mekanizmi antik. Një studim mbi aktivitetin elektrik të trurit i publikuar në Nature Communications mund të shpjegojë tashmë pse ndodh kjo gjë. Origjina e përbashkët Sipas Adam Aron nga Universiteti i […]

Study reveals factors that can make placenta less capable of protecting fetus from zika

Findings reported by Brazilian researchers in PLOS Neglected Tropical Diseases help explain why only some babies whose mothers are infected during pregnancy are born with microcephaly and other anomalies Credit: HUG-CELL/USP Genetic factors that reduce the placenta‘s capacity to protect the fetus from the zika virus are described by Brazilian researchers in an article published […]

New research predicts whether rheumatoid arthritis patients will respond to treatment

Credit: CC0 Public Domain A new study led by researchers at Queen Mary University of London provides potential novel biomarkers for predicting patient responsiveness to disease modifying anti-rheumatic drugs (DMARDs). Rheumatoid Arthritis (RA) patients are commonly treated with disease modifying anti-rheumatic drugs (DMARDs) despite the fact that up to 50% of patients are unresponsive to […]

Cerebrospinal fluid as liquid biopsy for characterizing and policing of medulloblastoma

Joan Seoane, Director of Translational Research, Vall d’Hebron Institute of Oncology (VHIO). Credit: VHIO Building on previous research 1—3 led by Joan Seoane, Director of Translational Research at the Vall d’Hebron Institute of Oncology (VHIO) and ICREA Research Professor, latest findings from a proof-of-concept study published in Nature Communications, show that the analysis of cerebrospinal […]

Single brain region links depression and anxiety, heart disease, and treatment sensitivity

The researchers used brain imaging to explore other brain regions affected by sgACC over-activity during threat. Over-activation of sgACC increased activity within the amygdala and hypothalamus, two key parts of the brain’s stress network. By contrast, it reduced activity in parts of the lateral prefrontal cortex – a region important in regulating emotional responses and […]

Blutgefäße gezielt und schnell vergrößern

Bei Herzinfarkten und Schlaganfällen muss die Blutversorgung möglichst schnell sichergestellt werden, um größere körperliche Schäden zu vermeiden. Zoologen des Karlsruher Instituts für Technologie (KIT) setzen auf einen neuen Mechanismus, um die Endothelzellen zu vergrößern und damit binnen Stunden den Blutdurchfluss zu verbessern. „Wir verfolgen einen völlig neuen Ansatz“, betont Prof. Ferdinand le Noble, Leiter der […]

Entwicklung neuer Methoden maschinellen Lernens für Entdeckungen in der Chemie

Prof. Alexandre Tkatchenko und sein Forschungsteam an der Universität Luxemburg haben Zuschüsse in Höhe von insgesamt 500.000 Euro für die Forschung auf dem Gebiet des maschinellen Lernens für Entdeckungen in der Chemie erhalten. Die Entdeckung und Entwicklung neuer Medikamente, antiviraler Mittel, Antibiotika und allgemein von Chemikalien mit spezifischen Eigenschaften ist ein langer und mühsamer Prozess. […]

New blood cancer treatment works by selectively interfering with cancer cell signalling

Credit: Pixabay/CC0 Public Domain University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published today in Nature Communications. The research team led by Luc Berthiaume, cell biology professor in the Faculty of Medicine & […]

Researchers find that patients with acne have reduced expression of the protein GATA6

Credit: Pixabay/CC0 Public Domain An international team of researchers has found that patients with acne have lower levels of expression of the protein GATA6 in their skin. In their paper published in the journal Nature Communications, the group describes their study of skin biopsies taken from acne patients and what they found. Acne is a […]

Map the fundamentals of how cells go awry

Credit: CC0 Public Domain Someday, scientists may be able to prevent cancer by controlling two proteins that operate deep inside the quagmire of epigenetic cell fate transitions, a new paper suggests. Published by Nature Communications, the article describes a dynamic push and pull between the proteins ANP32E and H2AZ. Their relationship is significant because too […]

Aggressive melanoma cells at edge of tumours are key to cancer spread

Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0 Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body. The findings from the study may help to […]

Research could change how blood pressure is managed in spinal cord injury patients

Credit: CC0 Public Domain New research from the International Collaboration on Repair Discoveries (ICORD) challenges the current standard for managing blood pressure in people with spinal cord injury (SCI). The findings, published today in Nature Communications, could lead to a change in the way newly injured patients have their blood pressure managed, potentially improving their […]

Researchers mine data and connect the dots about processes driving neuroblastoma

Michael Dyer, Ph.D., chair of the St. Jude Department of Developmental Neurobiology Credit: St. Jude Children’s Research Hospital October 14, 2020) Researchers have used insight from a comprehensive genomic analysis of neuroblastoma to learn about the process driving one of the most common childhood solid tumors. The findings revealed possible approaches for developing precision medicines […]

A team of researchers makes novel discoveries in preventing epileptic seizures

Sanjay Kumar, an associate professor in the Florida State University College of Medicine’s Department of Biomedical Sciences Credit: Colin Hackley A team of researchers from the Florida State University College of Medicine has found that an amino acid produced by the brain could play a crucial role in preventing a type of epileptic seizure. Temporal […]

Study details highest-risk groups for dying of COVID-19 in Sweden

Gunnar Andersson, professor of demography, Stockholm University. Credit: Leila Zoubir/Stockholm University Being a man, having a lower income, having a lower level of education, not being married, and being born abroad in low- or middle-income countries—these are factors that, independent of one another, are related to an elevated risk of dying from COVID-19 in Sweden. […]

Medikamente millimetergenau ins Gehirn bringen

Fokussierte Ultraschallwellen helfen ETH-​Forschenden, Medikamente im Gehirn punktgenau zu platzieren, also nur dort, wo ihre Wirkung erwünscht ist. Die Methode soll künftig psychiatrische, neurologische und onkologische Behandlungen mit weniger Nebenwirkungen ermöglichen. Forschende der ETH Zürich haben eine Methode entwickelt, mit der Medikamente im Hirn punktgenau freigesetzt werden können. Damit könnte es in Zukunft möglich werden, […]

Hospitalized COVID-19 patients are younger, healthier than influenza patients

Credit: Columbia University Irving Medical Center Patients hospitalized with COVID-19 were more likely male, younger, and, in both the US and Spain, had fewer comorbidities and lower medication use than hospitalized influenza patients according to a recent study published by the Observational Health Data Sciences and Informatics (OHDSI) community. OHDSI has established an international network […]

Supercharged ‘clones’ spark scarlet fever’s re-emergence

The University of Queensland’s Dr Stephan Brouwer is helping reveal why scarlet fever is making a comeback. Credit: The University of Queensland A University of Queensland-led team of international researchers says supercharged “clones” of the bacteria Streptococcus pyogenes are to blame for the resurgence of the disease, which has caused high death rates for centuries. […]

Nearly half of Amazon rainforest risks tipping into savanna, study says

Issued on: 06/10/2020 – 05:57 As much as 40 percent of the Amazon risks crossing a tipping point from rainforest to savanna as greenhouse gas emissions reduce the rainfall needed to sustain its unique ecosystem, scientists said Monday. Forests are particularly sensitive to changes that affect rainfall for extended periods, and trees may die off […]

Millimetre-precision drug delivery to the brain

Scheme of the two-step procedure for accumulating and finally releasing encapsulated drugs locally. (Source: Ozdas et al. Nature Communications 2020, adapted) Researchers at ETH Zurich have developed a method for concentrating and releasing drugs in the brain with pinpoint accuracy. This could make it possible in the future to deliver psychiatric and cancer drugs and […]

Exakte Genkontrolle durch Licht – Biermann Medizin

Ein neuartiger optischer Schalter erlaubt es, die Lebenszeit genetischer „Abschriften“ exakt zu kontrollieren. Diese dienen der Zelle als Bauanleitung für die Herstellung von Proteinen. Die Methode wurde von Wissenschaftlern der Universitäten Bonn und Bayreuth entwickelt. Sie könnte die Untersuchung dynamischer Prozesse in lebenden Zellen deutlich vorantreiben. Die Studie ist in der Zeitschrift Nature Communications erschienen. […]

Personalized cancer therapy improves outcomes in advanced disease, says study

Killer T cells surround a cancer cell. Credit: NIH Patients receiving care for advanced cancer at Moores Cancer Center at UC San Diego Health were more likely to survive or experience a longer period without their disease progressing if they received personalized cancer therapy, report University of California San Diego School of Medicine researchers. Led […]

Gut microbiome may influence how cancer patients respond to oral therapies, study suggests

Brendan Daisley, a PhD candidate at Western University’s Schulich School of Medicine & Dentistry who is conducting research at Lawson Health Research Institute Credit: Lawson Health Research Institute A new study from Lawson Health Research Institute and Western University illustrates how the gut microbiome interacts with an oral medication in prostate cancer patients, suggesting bacteria […]

160 genes linked to brain shrinkage in study of 45,000 adults

Credit: Unsplash/CC0 Public Domain A new study implicates 160 genes in brain shrinkage seen on MRIs of 45,000 healthy adults. The shrinkage is in the cortex, the dimply outer layer of the brain that gives rise to thinking, awareness and action, and largely consists of gray matter. The study, published Sept. 22 in the journal […]

Key discovery in psoriatic arthritis points way for developing targeted treatments

Credit: Unsplash/CC0 Public Domain A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause […]