A new study exposes how SARS-CoV-2 tampers with the cell’s hardware to outsmart the immune system — ScienceDaily


Severe symptoms of COVID-19, leading often to death, are thought to result from the patient’s own acute immune response rather than from damage inflicted directly by the virus. Immense research efforts are therefore invested in figuring out how the virus manages to mount an effective invasion while throwing the immune system off course. A new […]

Genomic analysis of human samples from dry caves shows stark differences with modern industrialized bacterial populations. — ScienceDaily


Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases. Now Joslin Diabetes Center scientists have found dramatic differences between gut microbiomes from ancient North American peoples and modern microbiomes, offering new evidence on how […]

Discovery of the mechanisms of short- and long-term anosmia — ScienceDaily


Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. But the mechanisms involved had yet to be clarified. Scientists from the Institut Pasteur, the CNRS, Inserm, Université de Paris and the Paris Public Hospital Network (AP-HP) determined the mechanisms involved in the loss of smell in patients […]

Researchers identify target for senolytic drugs — ScienceDaily


In a study recently published in Nature, University of Minnesota Medical School researchers found that senescent immune cells are the most dangerous type of senescent cell. Cells become senescent when they are damaged or stressed in the body, and they accumulate in our organs as we age. Senescent cells drive inflammation and aging as well […]

New research outlines a critical driver in an immune cell’s defense against melanoma — ScienceDaily


Today in Nature Communications, researchers at Huntsman Cancer Institute at the University of Utah report critical new insights into how cells mount an attack against melanoma tumors. Melanoma is an aggressive type of skin cancer that can arise from excess exposure to sun, frequent sunburns, genetics, and other environmental factors. Melanoma, like all cancers, begins […]

New study explores children’s perception of their own wellbeing using art — ScienceDaily


Young children in deprived areas see nature and outdoor spaces as being associated with “happy places,” according to a new study published in the journal Child Indicators Research. Researchers Dr Nicola Walshe and Dr Zoe Moula from Anglia Ruskin University (ARU) asked 91 children aged seven and eight from two primary schools in areas of […]

To enhance creativity, keep your research team fresh — ScienceDaily


Teamwork is becoming increasingly common in modern science. In this context, the effect of different characteristics of a team on its research performance has been studied extensively. Various factors such as team size, number of countries involved, universities, disciplines, and workload distribution have been found to have a significant contribution on the paper’s role in […]

Our quick scan of a crowd isn’t as reliable as we think, new research suggests — ScienceDaily


You enter a room and quickly scan the crowd to gain a sense of who’s there — how many men versus women. How reliable is your estimate? Not very, according to new research from Duke University. In an experimental study, researchers found that participants consistently erred in estimating the proportion of men and women in […]

New versions of light-sensitive proteins could illuminate the dark corners of our brain’s communication pathways — ScienceDaily


Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed […]

Study reveals structure of key receptors involved in memory and learning — ScienceDaily


Scientists have for the first time revealed the structure surrounding important receptors in the brain’s hippocampus, the seat of memory and learning. The study, carried out at Oregon Health & Science University, published today in the journal Nature. The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor […]

Brain computer interface turns mental handwriting into text on screen — ScienceDaily


Scientists are exploring a number of ways for people with disabilities to communicate with their thoughts. The newest and fastest turns back to a vintage means for expressing oneself: handwriting. For the first time, researchers have deciphered the brain activity associated with trying to write letters by hand. Working with a participant with paralysis who […]

Coronavirus UK: Could spread of Indian variant jeapordise plans to ease lockdown?


India‘s Covid variant is now dominant in four local authorities in England and its rapid spread could jeopardise plans to ease lockdown, experts fear. Analysis by one of the UK’s biggest variant trackers warns the strain is focused in hotspots Bolton and neighbour Blackburn with Darwen, where outbreaks have grown by 93 and 86 per […]

It happens during and after birth — ScienceDaily


It is well known that each person’s gut bacteria is vital for digestion and overall health, but when does that gut microbiome start? New research led by scientists from McMaster University and Charité — Universitätsmedizin Berlin in Germany has found it happens during and after birth, and not before. McMaster researchers Deborah Sloboda and Katherine […]

Lighting up biology from within — ScienceDaily


A biochemical reaction between an enzyme called luciferase and oxygen causes fireflies to glow and is considered one of the most well-known examples of bioluminescence in nature. Now, an international team of researchers led by Elena Goun at the University of Missouri is working to harness the power of bioluminescence in a low-cost, noninvasive portable […]

How to predict severe influenza in hospitalized patients — ScienceDaily


Published today in Nature Communications, the team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), Alfred Health and Monash University sought to understand which patients would recover quickly from influenza and which would become severely ill. The four-year project took samples from patients hospitalised with influenza at up to five time points […]

Proof-of-principle research shows that genes can be accurately edited in cells throughout the body — ScienceDaily


Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques. Working in fruit flies and human cells, research led by UC San Diego Postdoctoral Scholar Zhiqian Li in Division of Biological Sciences Professor Ethan Bier’s laboratory demonstrates that new DNA repair […]

A new approach for treating obesity — ScienceDaily


A receptor that helps conserve energy when food is scarce may be the key to a safer approach to treating diet-induced obesity, research led by the Garvan Institute of Medical Research has revealed. In a study using experimental models and fat tissue biopsies from obese individuals, the team revealed that blocking a specific receptor of […]

How one of the oldest natural insecticides keeps mosquitoes away — ScienceDaily


With mosquito season upon us, people are stocking up on repellents to prevent itchy bites. Bug repellents are important because they don’t just protect against the buzzing, blood-sucking little pests — they also safeguard against the diseases they carry, which kill some 700,000 people worldwide each year. Surprisingly, despite widespread use, no one understood exactly […]

Research could open the doors for a Trojan horse in cancer therapy — ScienceDaily


New research led by a team at Massachusetts General Hospital (MGH) points to a promising strategy to boost tumors’ intake of cancer drugs, thereby increasing the effectiveness of chemotherapy treatments. The group’s findings are published in Nature Nanotechnology. Getting enough anticancer drugs into a tumor is often difficult, and a potential strategy to overcome this […]

Researchers have determined the virus’ protein-coding gene set and analyzed new mutations’ likelihood of helping the virus adapt — ScienceDaily


In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2. While many of its genes were already known at that point, the full complement of protein-coding genes was unresolved. Now, after performing an extensive comparative genomics study, MIT […]

Could ECSTASY cure PTSD? Patients given party drug before counselling respond better to treatment


Giving ecstasy to people with post-traumatic stress disorder before counselling can relieve them of their symptoms within weeks, a study has suggested. Two-thirds of patients prescribed the illegal party drug alongside therapy no longer qualified for a PTSD diagnosis two months after treatment finished.  For comparison, 32 per cent who were given a placebo and […]

How proteins control information processing in the brain — ScienceDaily


A complicated interaction between different proteins is needed for information to pass from one nerve cell to the next. Researchers at the Martin Luther University Halle-Wittenberg (MLU) have now managed to study this process in the synaptic vesicles, which play an important role in this process. The study appeared in the journal Nature Communications. Several […]

Esophageal cancers resurrect ancient retroviruses hidden in our genome — ScienceDaily


Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago. “It was surprising,” says Adam Bass, MD, the Herbert and Florence Irving Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, who […]

New finding suggests cognitive problems caused by repeat mild head hits could be treated — ScienceDaily


A neurologic pathway by which non-damaging but high frequency brain impact blunts normal brain function and causes long-term problems with learning and memory has been identified. The finding suggests that tailored drug therapy can be designed and developed to reactivate and normalize cognitive function, say neuroscientists at Georgetown University Medical Center. The investigators, working with […]

Diagramming the brain with colorful connections — ScienceDaily


There are billions of neurons in the human brain, and scientists want to know how they are connected. Cold Spring Harbor Laboratory (CSHL) Alle Davis and Maxine Harrison Professor of Neurosciences Anthony Zador, and colleagues Xiaoyin Chen and Yu-Chi Sun, published a new technique in Nature Neuroscience for figuring out connections using genetic tags. Their […]

First optogenetics-based study of unrestricted social interactions within groups of animals — ScienceDaily


Northwestern University researchers are building social bonds with beams of light. For the first time ever, Northwestern engineers and neurobiologists have wirelessly programmed — and then deprogrammed — mice to socially interact with one another in real time. The advancement is thanks to a first-of-its-kind ultraminiature, wireless, battery-free and fully implantable device that uses light […]

First optogenetics-based study of unrestricted social interactions within groups of animals — ScienceDaily


Northwestern University researchers are building social bonds with beams of light. For the first time ever, Northwestern engineers and neurobiologists have wirelessly programmed — and then deprogrammed — mice to socially interact with one another in real time. The advancement is thanks to a first-of-its-kind ultraminiature, wireless, battery-free and fully implantable device that uses light […]

First optogenetics-based study of unrestricted social interactions within groups of animals — ScienceDaily


Northwestern University researchers are building social bonds with beams of light. For the first time ever, Northwestern engineers and neurobiologists have wirelessly programmed — and then deprogrammed — mice to socially interact with one another in real time. The advancement is thanks to a first-of-its-kind ultraminiature, wireless, battery-free and fully implantable device that uses light […]

Study in animals identifies a potential way to build vaccines to fight future pandemics — ScienceDaily


A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections — including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic. The new vaccine, called a pan-coronavirus vaccine, triggers […]

Biomarker detects severe COVID-19 early on — ScienceDaily


Severe cases of COVID-19 can now be detected at an early stage. Researchers at the University of Zurich have identified the first biomarker that can reliably predict which patients will develop severe symptoms. This can help to improve the treatment of severe cases of COVID-19. Most people who are infected with SARS-CoV-2 develop no or […]

TB immune response discovery could significantly reduce disease harm — ScienceDaily


A pioneering study by UCL scientists has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to infection, excessive and damaging lung inflammation caused by TB may be significantly reduced to help speed […]

Reaching your life goals as a single-celled organism — ScienceDaily


How is it possible to move in the desired direction without a brain or nervous system? Single-celled organisms apparently manage this feat without any problems: for example, they can swim towards food with the help of small flagellar tails. How these extremely simply built creatures manage to do this was not entirely clear until now. […]

Research results challenge a decades-old mechanism of how we hear sounds — ScienceDaily


Researchers at Linköping University, Sweden, have made several discoveries on the functioning mechanisms of the inner hair cells of the ear, which convert sounds into nerve signals that are processed in the brain. The results, presented in the scientific journal Nature Communications, challenge the current picture of the anatomical organisation and workings of the hearing […]

Process for eliminating unneeded cells may also protect against cancer — ScienceDaily


For all animals, eliminating some cells is a necessary part of embryonic development. Living cells are also naturally sloughed off in mature tissues; for example, the lining of the intestine turns over every few days. One way that organisms get rid of unneeded cells is through a process called extrusion, which allows cells to be […]

Using routinely acquired pathology slides, the model accurately predicts the origin of cancers with unknown primary tumors — ScienceDaily


In 1 to 2 percent of cancer cases, the primary site of tumor origin cannot be determined. Because many modern cancer therapeutics target primary tumors, the prognosis for a cancer of unknown primary (CUP) is poor, with a median overall survival of 2.7-to-16 months. In order to receive a more specific diagnosis, patients often must […]

Novel switch found in proteins with wide-ranging implications for medical treatments — ScienceDaily


Proteins perform a vast array of functions in the cell of every living organism with critical roles in almost every biological process. Not only do they run our metabolism, manage cellular signaling and are in charge of energy production, as antibodies they are also the frontline workers of our immune system fighting human pathogens like […]

C. albicans’ ability to shift forms can help it cause dangerous infections, and a study suggests that a protein called Sir2 aids this transition — ScienceDaily


You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast or propagate in an elongated form called hypha, consisting of thread-like filaments. This dual nature can help the pathogen survive in the body, where it can cause disease, including dangerous hospital-acquired infections. But how does […]

Defective epithelial barriers linked to two billion chronic diseases — ScienceDaily


Epithelial cells form the covering of most internal and external surfaces of the human body. This protective layer acts as a defense against invaders — including bacteria, viruses, environmental toxins, pollutants and allergens. If the skin and mucosal barriers are damaged or leaky, foreign agents such as bacteria can enter into the tissue and cause […]

Independent evolutionary origins of vertebrate dentitions — ScienceDaily


The origins of a pretty smile have long been sought in the fearsome jaws of living sharks which have been considered living fossils reflecting the ancestral condition for vertebrate tooth development and inference of its evolution. However, this view ignores real fossils which more accurately reflect the nature of ancient ancestors. New research led by […]

Researchers speed identification of DNA regions that regulate gene expression — ScienceDaily


St. Jude Children’s Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics. Researchers used the system to identify dozens of DNA regulatory elements that act together […]

Trial demonstrates early AI-guided detection of heart disease in routine practice — ScienceDaily


Heart disease can take a number of forms, but some types of heart disease, such as asymptomatic low ejection fraction, can be hard to recognize, especially in the early stages when treatment would be most effective. The ECG AI-Guided Screening for Low Ejection Fraction, or EAGLE, trial set out to determine whether an artificial intelligence […]

Skin and immune cells coordinate defenses against assault — ScienceDaily


As the human body’s largest organ, the skin is responsible for protecting against a wide range of possible infections on all fleshy surfaces, from head to toe. So how exactly does the skin organize its defenses against such an array of threats? A new Yale study shows that the epidermis, the outermost layer of skin, […]

Surprising sand fly find yields new species of bacteria — ScienceDaily


Researchers at North Carolina State University and the University of North Carolina Greensboro made a surprising finding while examining areas where sand flies rear their young: a new species of bacteria that is highly attractive to pregnant, or gravid, sand flies. The findings could advance the production of ecologically safe baits or traps to reduce […]

Researchers’ catalog of airway cell types could reveal targets for future genetic therapies — ScienceDaily


A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis. The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of […]

Why do some neurons degenerate and die in Alzheimer’s disease, but not others? — ScienceDaily


In the brain of a person with Alzheimer’s disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among those subtypes — mysteriously — some perish and some do not. Researchers at Gladstone Institutes […]

DR MICHAEL MOSLEY: How fasting could help cut your blood pressure


Regular readers of this column might wonder if I am ever so slightly obsessed with the microbiome, the billions of tiny creatures that live in our guts — and you’d be right. I’m fascinated by these extraordinary microbes, and the ongoing battle between the ‘good’ and the bad’ ones, that influences so much about us, […]

Finally, the proof Covid vaccines ARE safe when you’re pregnant


The message from health chiefs is clear: Covid-19 vaccines are safe for pregnant women. While a question mark hung over this vital detail earlier on in jab trials, today there is clear data to show there is no risk to mothers-to-be or their unborn children. It is a major step forwards in the battle against […]

New gene editing technique enables millions of genetic experiments to be performed simultaneously — ScienceDaily


Researchers have created a new gene editing tool called Retron Library Recombineering (RLR) that can generate up to millions of mutations simultaneously, and ‘barcodes’ mutant bacterial cells so that the entire pool can be screened at once. It can be used in contexts where CRISPR is toxic or not feasible, and results in better editing […]

Fiber-optic ultrasonic imaging probe for future nanoscale disease diagnostics — ScienceDaily


Scientists at the University of Nottingham have developed an ultrasonic imaging system, which can be deployed on the tip of a hair-thin optical fibre, and will be insertable into the human body to visualise cell abnormalities in 3D. The new technology produces microscopic and nanoscopic resolution images that will one day help clinicians to examine […]

Hippocampal maps predict context-dependent behavior — ScienceDaily


Successful navigation requires the ability to separate memories in a context-dependent manner. For example, to find lost keys, one must first remember whether the keys were left in the kitchen or the office. How does the human brain retrieve the contextual memories that drive behavior? J.B. Julian of the Princeton Neuroscience Institute at Princeton University, […]

Mouse study provides atlas to pinpoint neurons involved in neurodegenerative diseases — ScienceDaily


In a mouse study, National Institutes of Health researchers have identified and mapped a diverse spectrum of motor neurons along the spinal cord. These neurons, which send and receive messages throughout the body, include a subset that is susceptible to neurodegenerative diseases. Created with a genetic sequencing technique, the atlas reveals 21 subtypes of neurons […]

New genetic target for blood cancer treatment — ScienceDaily


Targeting a pathway that is essential for the survival of certain types of acute myeloid leukaemia could provide a new therapy avenue for patients, the latest research has found. Researchers from the Wellcome Sanger Institute found that a specific genetic mutation, which is linked with poor prognosis in blood cancer, is involved in the development […]

Results from phase two study show improved language and daily functioning among participants — ScienceDaily


An experimental treatment produced improvements in cognitive function and language in patients with fragile X syndrome, according to study results published on April 29 in Nature Medicine. Fragile X syndrome (known as FXS for short) is the most common known genetic cause of autism and the most common cause of inherited intellectual disability. “These results […]

Diseases affect brain’s networks selectively, BrainMap analysis affirms — ScienceDaily


The brain possesses a complex architecture of functional networks as its information-processing machinery. Is the brain’s network architecture itself a target of disease? If so, which networks are associated with which diseases? What can this tell us about the underlying causes of brain disorders? Building on the extraordinary progress in neuroscience made over the past […]

Single-cell CRISPR technology deciphers role of chromatin accessibility in cancer — ScienceDaily


In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. With this technology, […]

How does the brain flexibly process complex information? — ScienceDaily


Human decision-making depends on the flexible processing of complex information, but how the brain may adapt processing to momentary task demands has remained unclear. In a new article published in the journal Nature Communications, researchers from the Max Planck Institute for Human Development have now outlined several crucial neural processes revealing that our brain networks […]

Ky suplement mund t’ju ndihmojë të jetoni 13 për qind më gjatë


Acidet yndyrore Omega-3, që shpesh gjenden në suplementet e vajit të peshkut dhe prodhimet e tjera të detit, kanë marrë prej kohësh reputacionin se janë të dobishme për shëndetin fizik dhe mendor. Tani, një studim i ri tregon se sa thelbësore janë ato për mirëqenien e përgjithshme – përfshirë edhe jetëgjatësinë. Kërkimi i botuar së fundmi […]

How your tears may soon help save your life


Here’s a good reason to start crying with happiness: your tears could soon save your life by providing an early warning of cancer, diabetes and autoimmune disease. In future, they may even predict your risk of developing Alzheimer’s. And tears are not the only bodily secretions that are being used in a new generation of […]

Neural implant monitors multiple brain areas at once, provides new neuroscience insights — ScienceDaily


How do different parts of the brain communicate with each other during learning and memory formation? A new study by researchers at the University of California San Diego takes a first step at answering this fundamental neuroscience question. The study was made possible by developing a neural implant that monitors the activity of different parts […]

Ship traffic dropped during first months of COVID pandemic — ScienceDaily


Ship movements on the world’s oceans dropped in the first half of 2020 as Covid-19 restrictions came into force, a new study shows. Researchers used a satellite vessel-tracking system to compare ship and boat traffic in January to June 2020 with the same period in 2019. The study, led by the University of Exeter (UK) […]

New method preserves viable fruit fly embryos in liquid nitrogen — ScienceDaily


Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster) — which is crucial to genetics research and critical to scientific breakthroughs benefiting human health — has not been available. “To keep alive the ever-increasing […]

Tiny miracles saved by surgery in the womb


There could barely be worse news for a mother-to-be to receive. And because of pandemic regulations, Becky had to hear it alone. ‘The sonographer said: ‘I’m so sorry, there’s something seriously wrong with your baby and she is in imminent danger,’ ‘ the 28-year-old recalls. ‘I couldn’t stop crying.’ What should have been a routine mid-pregnancy […]

Study finds enhanced student communication and collaboration — ScienceDaily


A new paper on college science classes taught remotely points to teaching methods that enhance student communication and collaboration, offering a framework for enriching online instruction as the coronavirus pandemic continues to limit in-person courses. “These varied exercises allow students to engage, team up, get outside, do important lab work, and carry out group investigations […]

Research also challenges the idea that cell division is the main mechanism driving genetic changes — ScienceDaily


For the first time, scientists are able to study changes in the DNA of any human tissue, following the resolution of long-standing technical challenges by scientists at the Wellcome Sanger Institute. The new method, called nanorate sequencing (NanoSeq), makes it possible to study how genetic changes occur in human tissues with unprecedented accuracy. The study, […]

Impaired drainage also may play a role in Alzheimer’s in people — ScienceDaily


Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from the brain, according to a […]

Researchers find that people with the learning disorder sample visual material slower and with more difficulty — ScienceDaily


Researchers have long noted that readers with dyslexia employ eye movements that are significantly different from non-dyslexics. While these movements have been studied in small sample sizes in the past, a new paper written by Concordia researchers and published in the Nature journal Scientific Reports looks at a much larger group. The study used eye-tracking […]

Changing views on atherosclerosis — ScienceDaily


Peter Libby, MD, cardiovascular medicine specialist at Brigham and Women’s Hospital and the Mallinckrodt Professor of Medicine at Harvard Medical School; author of a new review paper published in Nature. Atherosclerosis — hardening of the arteries — is now involved in the majority of deaths worldwide, and advances in our understanding of the biology of […]

New study parses out when customers may feel undue persuasion and reduce their willingness to purchase a product — ScienceDaily


Product marketers should be clear in their messaging to avoid customer skepticism that makes them feel duped, according to University of Oregon research. At issue in a new study, published in the Journal of Business Research, was a social-cognitive construct called theory of mind, which considers how well people assess the mental states and apparent […]

Salad or cheeseburger? Your co-workers shape your food choices — ScienceDaily


The foods people buy at a workplace cafeteria may not always be chosen to satisfy an individual craving or taste for a particular food. When co-workers are eating together, individuals are more likely to select foods that are as healthy — or unhealthy — as the food selections on their fellow employees’ trays. “We found […]

Newly-discovered molecule provides dual protection against vascular inflammation — ScienceDaily


A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity. The study, published in the journal Nature Communications, revealed how one gene encoded two molecules […]

Force transmission between cells orchestrates collective cellular motion — ScienceDaily


How do the billions of cells communicate in order to perform tasks? The cells exert force on their environment through movement — and in doing so, they communicate. They work as a group in order to infiltrate their environment, perform wound healing and the like. They sense the stiffness or softness of their surroundings and […]

Removing ‘garbage’ from brain cells improves memory in mice — ScienceDaily


Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer’s disease in mice. The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting and recycling them. The study was published online today in the journal Cell. “Discoveries in mice don’t […]

Freeze! Executioner protein caught in the act — ScienceDaily


A new molecular ‘freeze frame’ technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells. Small proteins called ‘monobodies’ were used to freeze MLKL at different stages as it moved from a dormant to an activated state, a key process that enables an inflammatory form of cell death called […]

Major study details numerous long-term effects of COVID-19, pointing to massive health burden — ScienceDaily


As the COVID-19 pandemic has progressed, it has become clear that many survivors — even those who had mild cases — continue to manage a variety of health problems long after the initial infection should have resolved. In what is believed to be the largest comprehensive study of long COVID-19 to date, researchers at Washington […]

Reduced emissions from halving drainage depths would be equivalent to 1% of all anthropogenic greenhouse gases — ScienceDaily


Substantial cuts in global greenhouse gas emissions could be achieved by raising water levels in agricultural peatlands, according to a new study in the journal Nature. Peatlands occupy just three per cent of the world’s land surface area but store a similar amount of carbon to all terrestrial vegetation, as well as supporting unique biodiversity. […]

Science and need — not wealth or nationality — should guide vaccine allocation and prioritization, say experts — ScienceDaily


Ensuring COVID-19 vaccine access for refugee and displaced populations, and addressing health inequities, is vital for an effective pandemic response. Yet, vaccine allocation and distribution has been neither equitable nor inclusive, despite that global leaders have stressed this as a critical aspect to globally overcoming the pandemic, according to a paper published by Columbia University […]

New insights on inflammation in COVID-19 — ScienceDaily


Severe cases of COVID-19 can involve extensive inflammation in the body, and clinicians have wondered if this state is similar to what are called cytokine storm syndromes, in which the immune system produces too many inflammatory signals that can sometimes lead to organ failure and death. A new study published in Arthritis & Rheumatology indicates […]

‘Information theory’ recruited to help scientists find cancer genes — ScienceDaily


Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL). ALL is the most […]

‘Undruggable’ cancer protein becomes druggable, thanks to shrub — ScienceDaily


A chemist from Purdue University has found a way to synthesize a compound to fight a previously “undruggable” cancer protein with benefits across a myriad of cancer types. Inspired by a rare compound found in a shrub native to North America, Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for […]

Drug development platform could provide flexible, rapid and targeted antimicrobials — ScienceDaily


When disease outbreaks happen, response time in developing and distributing treatments is crucial to saving lives. Unfortunately, developing custom drugs as countermeasures is often a slow and difficult process. But researchers at the University of Colorado Boulder have created a platform that can develop effective and highly specific peptide nucleic acid therapies for use against […]

Organ tissues become increasingly immune throughout life — ScienceDaily


University of Minnesota Medical School researchers have offered new ways to think about the immune system thanks to a recent study published in Nature. Their research, which indicates organ tissues become increasingly immune throughout life, may begin to alter fundamental ideas regarding the rules of vaccination and the immune system’s function within the body. Saythi […]

Differing immune responses discovered in asymptomatic cases vs those with severe COVID-19 — ScienceDaily


The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus. Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL’s European Bioinformatics Institute (EMBL-EBI) and their […]

Combination of special cooling panels and natural ventilation can minimize disease transmission while saving energy — ScienceDaily


A novel system of chilled panels that can replace air conditioning can also help reduce the risk of indoor disease transmission, suggests new analysis from the University of British Columbia, University of Pennsylvania and Princeton University. The researchers computed air conditioning requirements in 60 of the world’s most populous cities — with the additional ventilation […]

Scientists find brain’s immune cells form some plaques as a defense in Alzheimer’s, suggesting a new therapeutic direction — ScienceDaily


One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they’ve largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why […]

New safer blood test is close to 100 per cent accurate at spotting nut allergies 


A new blood test promises to diagnose food allergies more accurately and offer a safer alternative to current testing practices. A trial by doctors at Guy’s and St Thomas’ Hospital in London has found that the test — called the basophil activation test (BAT) — is close to 100 per cent accurate at spotting nut […]

Latest remedy for eczema – rub bacteria on to your skin! 


Scientists have developed an unlikely treatment for the dry skin condition eczema — a cream that is packed with human skin bacteria. Studies suggest a healthy strain of skin bacteria can effectively treat flare-ups in people with the most common form of eczema, called atopic dermatitis, which affects 15 million people in the UK. The […]

New type of cell contributes to increased understanding of ALS — ScienceDaily


The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and […]

New software will allow creation of more complex devices — ScienceDaily


Someday, scientists believe, tiny DNA-based robots and other nanodevices will deliver medicine inside our bodies, detect the presence of deadly pathogens, and help manufacture increasingly smaller electronics. Researchers took a big step toward that future by developing a new tool that can design much more complex DNA robots and nanodevices than were ever possible before […]

Microglia, Stockholm syndrome and miraculous cures in glioblastoma patients — ScienceDaily


Despite access to some of the best possible medical care in the world, Senators John McCain and Edward Kennedy both died within 18 months of their diagnosis of glioblastoma, an aggressive form of brain cancer. While this deadly outcome typifies the nature of this disease, some glioblastoma patients see exceptional benefits from chemotherapy and survive […]

Intellectual disability is rarely inherited — risk for younger siblings is low — ScienceDaily


The prevalence of intellectual disabilities, which means difficulties with learning and understanding new things, is roughly 1-2% in the population. People with a severe intellectual disability need help from others in daily activities throughout their lives. Such disabilities can be caused by genetic changes or external factors. According to estimates, roughly 2,500 genes underlie intellectual […]

Pandemic eviction bans found to protect entire communities from COVID-19 spread — ScienceDaily


A new study led by researchers at Johns Hopkins and the University of Pennsylvania uses computer modeling to suggest that eviction bans authorized during the COVID-19 pandemic reduced the infection rate and not only protected those who would have lost their housing but also entire communities from the spread of infections. With widespread job loss […]

MK-4482 shows potential to prevent and treat SARS-CoV-2 infection — ScienceDaily


The experimental antiviral drug MK-4482 significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection, according to a new study from National Institutes of Health scientists. SARS-CoV-2 is the virus that causes COVID-19. MK-4482, delivered orally, is now in human clinical trials. Remdesivir, an antiviral drug already approved […]

Protein found to control drivers of normal growth and cancer — ScienceDaily


Researchers have found a long-sought enzyme that prevents cancer by enabling the breakdown of proteins that drive cell growth, and that causes cancer when disabled. Publishing online in Nature on April 14, the new study revolves around the ability of each human cell to divide in two, with this process repeating itself until a single […]

Research could pave way for future treatments for alcohol use disorder — ScienceDaily


The slurred speech, poor coordination, and sedative effects of drinking too much alcohol may actually be caused by the breakdown of alcohol products produced in the brain, not in the liver as scientists currently think. That is the finding of a new study led by researchers from the University of Maryland School of Medicine (UMSOM) […]

New method of artificially creating genetic switches for yeast — ScienceDaily


A group of researchers from Kobe University and Chiba University has successfully developed a flexible and simple method of artificially producing genetic switches for yeast, a model eukaryotic organism. The group consisted of Researcher TOMINAGA Masahiro*1, Associate Professor ISHII Jun*2 and Professor KONDO Akihiko*3 (of Kobe University’s Graduate School of Science, Technology and Innovation/Engineering Biology […]

Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos — ScienceDaily


The DNA molecule is not naked in the nucleus. Instead, it is folded in a very organized way by the help of different proteins to establish a unique spatial organization of the genetic information. This 3D spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by […]

First noninvasive measurements of fast brain signals — ScienceDaily


The brain processes information using both slow and fast currents. Until now, researchers had to use electrodes placed inside the brain in order to measure the latter. For the first time, researchers from Charité — Universitätsmedizin Berlin and the Physikalisch-Technische Bundesanstalt (PTB), successfully visualized these fast brain signals from the outside — and found a […]

Lipid research may help solve COVID-19 vaccine challenges — ScienceDaily


New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain COVID-19 vaccines worldwide — the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online April 13 in Nature Communications, the researchers demonstrate a new, inexpensive […]

The device, which is powered by ultrasonic waves, could help doctors monitor the health of transplanted organs and tissue — ScienceDaily


Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and powered by ultrasound waves, could help doctors monitor the health of transplanted organs or tissue and provide an early […]

From Denisovans to the human immune response — ScienceDaily


Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution. However, the vast majority of genetic studies have been focused on populations of European ancestry, which represent only 16% of the global population. Scientists at the Institut Pasteur, Collège de France, and CNRS have looked […]