Low levels of a simple sugar — A new biomarker for severe MS? — ScienceDaily

Multiple sclerosis, or MS for short, manifests itself slightly differently in each person — which is why some call it “the disease of a thousand faces.” Arguably the worst manifestation of MS is its chronic progressive form. Unlike the more common relapsing-remitting variant (RRMS), in which sufferers are often symptom-free for months or even years, […]

Study compares epigenetic modifications to DNA in the cerebellum of humans, chimpanzees and monkeys — ScienceDaily

The cerebellum — a part of the brain once recognized mainly for its role in coordinating movement — underwent evolutionary changes that may have contributed to human culture, language and tool use. This new finding appears in a study by Elaine Guevara of Duke University and colleagues, published May 6th in the journal PLOS Genetics. […]

New evidence links gut bacteria and neurodegenerative conditions — ScienceDaily

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS affect millions of adults, but scientists still do not know what causes these diseases, which poses a significant roadblock to developing treatments or preventative measures. Recent research suggests that people with these conditions exhibit changes in the bacterial composition of their digestive tract. However, given the vast […]

Why do some neurons degenerate and die in Alzheimer’s disease, but not others? — ScienceDaily

In the brain of a person with Alzheimer’s disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among those subtypes — mysteriously — some perish and some do not. Researchers at Gladstone Institutes […]

Protein linked to sex differences in age-related dopamine neuron loss — ScienceDaily

It is not every day that scientists come across a phenomenon so fundamental that it is observed across fruit flies, rodents and humans. In a paper published today in Aging Cell, neuroscientists from the University of Pittsburgh Schools of the Health Sciences discovered that a single protein — a glutamate transporter on the membrane of […]

Mouse study provides atlas to pinpoint neurons involved in neurodegenerative diseases — ScienceDaily

In a mouse study, National Institutes of Health researchers have identified and mapped a diverse spectrum of motor neurons along the spinal cord. These neurons, which send and receive messages throughout the body, include a subset that is susceptible to neurodegenerative diseases. Created with a genetic sequencing technique, the atlas reveals 21 subtypes of neurons […]

Researchers identify protein produced after stroke that triggers neurodegeneration — ScienceDaily

Researchers with the Peter O’Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke. Scientists from the departments of pathology, neurology, biochemistry, and pharmacology at UTSW have identified and named […]

Impaired drainage also may play a role in Alzheimer’s in people — ScienceDaily

Experimental Alzheimer’s drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations. But new research in mice has shown that some investigational Alzheimer’s therapies are more effective when paired with a treatment geared toward improving drainage of fluid — and debris — from the brain, according to a […]

A gene finding links severe canine juvenile epilepsy to mitochondrial dysfunction — ScienceDaily

In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps. Concurrently, amyloid-β accumulation and widespread neurodegeneration associated with […]

Study finds evidence of more brain aging in people living in disadvantaged areas — ScienceDaily

Middle-age and older people living in more disadvantaged neighborhoods — areas with higher poverty levels and fewer educational and employment opportunities — had more brain shrinkage on brain scans and showed faster decline on cognitive tests than people living in neighborhoods with fewer disadvantages, according to a study published in the April 14, 2021, online […]

Potential mechanistic link shown between Traumatic Brain Injury and Alzheimer’s disease — ScienceDaily

Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with some form of chronic impairment after suffering a TBI. Even in a mild form, TBI can lead to lifelong nerve cell deterioration associated with a wide array of neuropsychiatric […]

Dapansutril kann entzündliche Reaktionen im Gehirn von Mäusen verhindern

Neuroinflammation spielt beim Verlauf der Alzheimer-Krankheit eine wichtige Rolle. Forschende der Technischen Universität Braunschweig konnten in einer Studie mit Mäusen zeigen, dass die Substanz Dapansutril solche Entzündungsprozesse im Gehirn verhindern kann.  Um Krankheitserreger unschädlich zu machen, aktivieren Immunzellen des Gehirns spezielle Proteinkomplexe, die Inflammasome. Diese lösen eine Neuroinflammation aus, die in der Regel mit der […]

Krankheitsgen identifiziert: CLCN6-Mutation als Ursache lysosomal bedingter Neurodegeneration

Eine Mutation im CLCN6-Gen ist Ursache einer besonders schweren neurodegenerativen Form der lysosomalen Erbkrankheit. Diesen Nachweis haben jetzt Wissenschaftler vom Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) und vom Max-Delbrück-Centrum für Molekulare Medizin (MDC) zusammen mit einem internationalen Forscherteam erbracht, nachdem bei drei betroffenen Kindern die gleiche Punktmutation gefunden wurde. Unter dem Begriff „lysosomale Speicherkrankheit“ werden eine […]

Early, late stages of degenerative diseases are distinct, study shows

Based on thousands of experiments over more than a decade, Rice University biochemists Michael Stern and James McNew believe degenerative diseases as varied as Alzheimer’s, Parkinson’s and muscle atrophy occur in two phases (green and red) marked by distinct alterations in the activity of the signaling pathway proteins TOR, AMPK, Foxo and JNK. In the […]

Kliniken Schmieder Allensbach mit neuer Leitung der Neuroradiologie

Prof. Christoph Stippich übernimmt die Abteilung Neuroradiologie und Radiologie der Kliniken Schmieder Allensbach. (Foto: Kliniken Schmieder) Prof. Christoph Stippich übernimmt die Abteilung Neuroradiologie und Radiologie der Kliniken Schmieder Allensbach. Seit Anfang Oktober 2020 ist Prof. Christoph Stippich Ärztlicher Leiter der radiologischen Abteilung der Kliniken Schmieder Allensbach. Zuletzt war Stippich Direktor der Klinik für Neuroradiologie am Universitätsspital […]

Neue Klasse von Hemmstoffen schützt vor Neurodegeneration

Heidelberger Neurobiologen entschlüsseln im Mausmodell zentralen Mechanismus degenerativer Prozesse im Gehirn und entwickeln neues therapeutisches Wirkstoffprinzip. Wie ein spezieller Rezeptor, der in den Synapsen üblicherweise ein genetisches Schutzprogramm anschaltet, außerhalb synaptischer Kontakte zum Nervenzelltod führen kann, haben Neurobiologen der Universität Heidelberg aufgeklärt. Ihre grundlegenden Erkenntnisse zu neurodegenerativen Prozessen führten die Forscher des Interdisziplinären Zentrums für […]

Detecting neurodegeneration biomarkers through magnetic resonance imaging

This tool is able to identify single-person neurodegeneration before the symptom’s appearance, which could significate a more effective and personalized medicine. Credit: Bellvitge Biomedical Research Institute (IDIBELL) Magnetic resonance imaging is the most sensitive and reliable technique for diagnosing and monitoring neurodegenerative diseases. Through the images obtained, clinicians can make a complete anatomical analysis of […]

Mehr als die üblichen Verdächtigen

Forscher haben die Wechselwirkungen bislang bekannter, für neurodegenerative Erkrankungen verantwortlicher Proteine mit anderen Eiweißen untersucht. Das hat den Kreis der Verdächtigen deutlich vergrößert. Auslöser neurodegenerativer Erkrankungen wie Alzheimer, Parkinson, Chorea Huntington oder Amyotrophe Lateralsklerose (ALS) sind fehlgefaltete, miteinander verklumpte Proteine, die sich im Nervengewebe ablagern. Sie verursachen dort schwere Schäden, Nervenzellen sterben ab. Die Symptome: […]

160 genes linked to brain shrinkage in study of 45,000 adults

Credit: Unsplash/CC0 Public Domain A new study implicates 160 genes in brain shrinkage seen on MRIs of 45,000 healthy adults. The shrinkage is in the cortex, the dimply outer layer of the brain that gives rise to thinking, awareness and action, and largely consists of gray matter. The study, published Sept. 22 in the journal […]

A genetic variant that protects against Alzheimer’s disease promotes immune cell functions

Credit: Unsplash/CC0 Public Domain A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies […]