Connecting genetic variants to changes in expression levels to understand immune-mediated diseases — ScienceDaily


[ad_1] Researchers in Japan have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. This resource will allow experts to more deeply understand how immune disorders develop and plan future drug discovery projects. Scientists also hope this atlas of immune-related genome data may eventually be applied to investigations of infectious diseases like COVID-19. “To […]

SARS-CoV-2 curtails immune response in the gut — ScienceDaily


[ad_1] In an effort to determine the potential for COVID-19 to begin in a person’s gut, and to better understand how human cells respond to SARS-CoV-2, the scientists used human intestinal cells to create organoids — 3D tissue cultures derived from human cells, which mimic the tissue or organ from which the cells originate. Their […]

New technique models brain cells in older patients more accurately than ever before — ScienceDaily


[ad_1] Despite the prevalence of Alzheimer’s, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists at the Salk Institute have uncovered new insights into what goes awry during Alzheimer’s by growing neurons that resemble — more accurately than ever before — brain cells in […]

Research shows exposure to high temperatures can neutralize the virus, preventing it from infecting another human host — ScienceDaily


[ad_1] Arum Han, professor in the Department of Electrical and Computer Engineering at Texas A&M University, and his collaborators have designed an experimental system that shows exposure of SARS-CoV-2 to a very high temperature, even if applied for less than a second, can be sufficient to neutralize the virus so that it can no longer […]

New model may explain the mystery of asymmetry in Parkinson’s disease — ScienceDaily


[ad_1] Parkinson’s disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD described in this review article published in the Journal of Parkinson’s Disease may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders. […]

New type of cell contributes to increased understanding of ALS — ScienceDaily


[ad_1] The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous […]

Scientists identify human genes that fight infection — ScienceDaily


[ad_1] Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers’ understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the […]

New discovery could lead to therapies for patients with Duchenne muscular dystrophy — ScienceDaily


[ad_1] A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, “A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression,” the study […]

A novel, quick, and easy system for genetic analysis of SARS-CoV-2 — ScienceDaily


[ad_1] SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have? Current methods for studying mutations in the SARS-CoV-2 genome are very complicated and time-consuming because coronaviruses have large genomes, but now a team from Osaka […]

There is no ‘one size fits all’ approach to treat severe asthma — ScienceDaily


[ad_1] Wheezing, coughing that doesn’t stop, a pale and sweaty face: clinically, severe asthma attacks look very similar from patient to patient. But biologically, not all severe asthma is the same — and a team of scientists has, for the first time, identified the key difference in people, a finding that has important implications for […]

Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease — ScienceDaily


[ad_1] A new study published in the Journal of Alzheimer’s Disease Reports continues to support a growing body of evidence that aluminum contributes to the pathogenesis of Alzheimer’s disease (AD). Researchers found aluminum co-located with phosphorylated tau protein, which is an early initiator of AD. This study builds upon two earlier published studies (including Mold […]

Why 2020 was the year of marvellous medicine


[ad_1] A year ago, the world was in the grip of a deadly and, seemingly, unstoppable virus and the UK went into its first lockdown.  Since then, vaccines and life-saving drugs to counter Covid have been the focus of international attention.  But the past year has also seen major developments in treatments for cancer, diabetes, […]

Parasitic worms offer ‘the missing link’ on the dual nature of a key immune regulator


[ad_1] Samples of nasal polyps removed from patients with chronic rhinosinusitis revealed the perforin-2 protein (labeled in green) in the cellular plasma membrane. A pore protein, perforin-2 may be how IL-33, a key immune signaling molecule, is able to exit these cells to trigger an immune response, according to new work led by a Penn […]

Mimicking SARS-CoV-2 nasal infection in monkeys


[ad_1] A rhesus macaque. Credit: Pixabay user RobbieRoss A new rhesus macaque animal model recapitulates the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) observed in humans by mimicking natural infection via the nasal route, according to a study published November 12 in the open-access journal PLOS Pathogens by Longding Liu, Qihan Li, Zhanlong […]

Scientists identify protein that protects against Lyme


[ad_1] Credit: CC0 Public Domain Yale researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection, they report Nov. 11 in the journal PLOS Pathogens. Lyme Disease is the most common vector-borne disease in North America […]

Children produce different antibodies in response to SARS-CoV-2


[ad_1] Credit: Pixabay/CC0 Public Domain Children and adults produce different types and amounts of antibodies in response to infection with the new coronavirus, SARS-CoV-2, a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons has found. The differences in antibodies suggest the course of the infection and immune response is distinct […]

The link between glaucoma, the immune system and protein tenascin-C


[ad_1] With their experiments the researchers gained new insights into the interplay of the extracellular protein tenascin-C and glaucoma. Credit: RUB, Marquard Researchers at Ruhr-Universität Bochum (RUB) have studied the role of the immune response in the development of glaucoma in mice. They showed that inflammatory processes are associated with the pathogenesis of the disease […]

Researchers find that patients with acne have reduced expression of the protein GATA6


[ad_1] Credit: Pixabay/CC0 Public Domain An international team of researchers has found that patients with acne have lower levels of expression of the protein GATA6 in their skin. In their paper published in the journal Nature Communications, the group describes their study of skin biopsies taken from acne patients and what they found. Acne is […]

Skeletal muscle development and regeneration mechanisms vary by gender


[ad_1] ERβ controls muscle growth in young female miceERβ is essential for muscle regeneration in female miceInactivation of ERβ causes an increase in apoptosisERβ is required for satellite cell population expansion Credit: Associate Professor Yusuke Ono Researchers at Kumamoto University, Japan, have generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle […]